Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response
Inflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. During liver injury, inflammatory cells are recruited in the injurious site through chemokines attraction. Thus, inflammation could be...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/943497 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556996024336384 |
|---|---|
| author | Florent Duval Jorge E. Moreno-Cuevas María Teresa González-Garza Carmen Maldonado-Bernal Delia Elva Cruz-Vega |
| author_facet | Florent Duval Jorge E. Moreno-Cuevas María Teresa González-Garza Carmen Maldonado-Bernal Delia Elva Cruz-Vega |
| author_sort | Florent Duval |
| collection | DOAJ |
| description | Inflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. During liver injury, inflammatory cells are recruited in the injurious site through chemokines attraction. Thus, inflammation could be a target to reduce liver fibrosis. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. The aim of this review is to describe the role of inflammation and the immune response in the pathogenesis of liver fibrosis and detail the mechanisms of inhibition of both events by medicinal plants in order to reduce liver fibrosis. |
| format | Article |
| id | doaj-art-f574283bdf774699b85ed70a9d372eaa |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-f574283bdf774699b85ed70a9d372eaa2025-02-03T05:43:54ZengWileyInternational Journal of Inflammation2090-80402042-00992015-01-01201510.1155/2015/943497943497Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune ResponseFlorent Duval0Jorge E. Moreno-Cuevas1María Teresa González-Garza2Carmen Maldonado-Bernal3Delia Elva Cruz-Vega4Catedra de Terapia Celular, Escuela de Medicina, Tecnológico de Monterrey, Avenida Morones Prieto 3000 Pte., 64710 Monterrey, NL, MexicoCatedra de Terapia Celular, Escuela de Medicina, Tecnológico de Monterrey, Avenida Morones Prieto 3000 Pte., 64710 Monterrey, NL, MexicoCatedra de Terapia Celular, Escuela de Medicina, Tecnológico de Monterrey, Avenida Morones Prieto 3000 Pte., 64710 Monterrey, NL, MexicoLaboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez 162, 06720 Ciudad de México, DF, MexicoCatedra de Terapia Celular, Escuela de Medicina, Tecnológico de Monterrey, Avenida Morones Prieto 3000 Pte., 64710 Monterrey, NL, MexicoInflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. During liver injury, inflammatory cells are recruited in the injurious site through chemokines attraction. Thus, inflammation could be a target to reduce liver fibrosis. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. The aim of this review is to describe the role of inflammation and the immune response in the pathogenesis of liver fibrosis and detail the mechanisms of inhibition of both events by medicinal plants in order to reduce liver fibrosis.http://dx.doi.org/10.1155/2015/943497 |
| spellingShingle | Florent Duval Jorge E. Moreno-Cuevas María Teresa González-Garza Carmen Maldonado-Bernal Delia Elva Cruz-Vega Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response International Journal of Inflammation |
| title | Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response |
| title_full | Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response |
| title_fullStr | Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response |
| title_full_unstemmed | Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response |
| title_short | Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune Response |
| title_sort | liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response |
| url | http://dx.doi.org/10.1155/2015/943497 |
| work_keys_str_mv | AT florentduval liverfibrosisandmechanismsoftheprotectiveactionofmedicinalplantstargetinginflammationandtheimmuneresponse AT jorgeemorenocuevas liverfibrosisandmechanismsoftheprotectiveactionofmedicinalplantstargetinginflammationandtheimmuneresponse AT mariateresagonzalezgarza liverfibrosisandmechanismsoftheprotectiveactionofmedicinalplantstargetinginflammationandtheimmuneresponse AT carmenmaldonadobernal liverfibrosisandmechanismsoftheprotectiveactionofmedicinalplantstargetinginflammationandtheimmuneresponse AT deliaelvacruzvega liverfibrosisandmechanismsoftheprotectiveactionofmedicinalplantstargetinginflammationandtheimmuneresponse |