Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome.
<h4>Background</h4>Despite previous clinical studies providing some evidence of an association between metformin treatment and polycystic ovary syndrome(PCOS), these findings remain controversial. To investigate whether the association reflect causality, a two-sample Mendelian randomizat...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0321380 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186800397549568 |
|---|---|
| author | Liting Lin Huan Shen Yanbin Wang |
| author_facet | Liting Lin Huan Shen Yanbin Wang |
| author_sort | Liting Lin |
| collection | DOAJ |
| description | <h4>Background</h4>Despite previous clinical studies providing some evidence of an association between metformin treatment and polycystic ovary syndrome(PCOS), these findings remain controversial. To investigate whether the association reflect causality, a two-sample Mendelian randomization (MR) method was conducted.<h4>Methods</h4>Data from genome-wide association studies were analyzed, with the exposure factor being metformin and the outcome variable being PCOS. The inverse variance weighted(IVW) was used as the primary method for MR analysis. In addition, MR-Egger, weighted median, heterogeneity tests, and sensitivity analyses were performed.<h4>Results</h4>The initial and validation MR analyses indicated that genetically predicted metformin treatment had no effects on PCOS. Sensitivity analyses provided additional confirmation of the reliability of the MR results.<h4>Conclusions</h4>Our two-sample MR analysis did not find genetic evidence supporting a significant association between metformin treatment and PCOS. |
| format | Article |
| id | doaj-art-f562e6396b0a44a79f17888bcc7f514a |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-f562e6396b0a44a79f17888bcc7f514a2025-08-20T02:16:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01204e032138010.1371/journal.pone.0321380Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome.Liting LinHuan ShenYanbin Wang<h4>Background</h4>Despite previous clinical studies providing some evidence of an association between metformin treatment and polycystic ovary syndrome(PCOS), these findings remain controversial. To investigate whether the association reflect causality, a two-sample Mendelian randomization (MR) method was conducted.<h4>Methods</h4>Data from genome-wide association studies were analyzed, with the exposure factor being metformin and the outcome variable being PCOS. The inverse variance weighted(IVW) was used as the primary method for MR analysis. In addition, MR-Egger, weighted median, heterogeneity tests, and sensitivity analyses were performed.<h4>Results</h4>The initial and validation MR analyses indicated that genetically predicted metformin treatment had no effects on PCOS. Sensitivity analyses provided additional confirmation of the reliability of the MR results.<h4>Conclusions</h4>Our two-sample MR analysis did not find genetic evidence supporting a significant association between metformin treatment and PCOS.https://doi.org/10.1371/journal.pone.0321380 |
| spellingShingle | Liting Lin Huan Shen Yanbin Wang Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome. PLoS ONE |
| title | Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome. |
| title_full | Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome. |
| title_fullStr | Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome. |
| title_full_unstemmed | Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome. |
| title_short | Mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome. |
| title_sort | mendelian randomization study showed no causality between metformin treatment and polycystic ovary syndrome |
| url | https://doi.org/10.1371/journal.pone.0321380 |
| work_keys_str_mv | AT litinglin mendelianrandomizationstudyshowednocausalitybetweenmetformintreatmentandpolycysticovarysyndrome AT huanshen mendelianrandomizationstudyshowednocausalitybetweenmetformintreatmentandpolycysticovarysyndrome AT yanbinwang mendelianrandomizationstudyshowednocausalitybetweenmetformintreatmentandpolycysticovarysyndrome |