Commensalism of Fusobacterium nucleatum - The dilemma
Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium that serves as a periodontal pathogen and plays a key role in linking Gram-positive and Gram-negative bacteria within the periodontal biofilm. It was shown that Fusobacterium produces significant amounts of butyric acid, which is a grea...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-07-01
|
| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jisp.jisp_286_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087192798756864 |
|---|---|
| author | Sangeeta Nayak Nishmitha D. Shetty Deepa G. Kamath |
| author_facet | Sangeeta Nayak Nishmitha D. Shetty Deepa G. Kamath |
| author_sort | Sangeeta Nayak |
| collection | DOAJ |
| description | Fusobacterium nucleatum is a Gram-negative, anaerobic bacterium that serves as a periodontal pathogen and plays a key role in linking Gram-positive and Gram-negative bacteria within the periodontal biofilm. It was shown that Fusobacterium produces significant amounts of butyric acid, which is a great source of energy for anti-inflammatory cells. On the other hand, it is associated with the destruction of periodontal structures. This bacterium can enter the blood circulation as a result of periodontal infection. It could cause numerous conditions such as halitosis, dental pulp infection, oral cancer, and systemic diseases. The present review discusses the virulence mechanisms involved in the diseases, with emphasis on its colonization, systemic dissemination, and induction of host inflammatory and tumorigenic responses. This would motivate future research on the role of this bacterium on periodontal pathology as well as its influence on the evolution of systemic diseases. |
| format | Article |
| id | doaj-art-f56210c4a0b84f39abe2c92f5372d662 |
| institution | Kabale University |
| issn | 0972-124X 0975-1580 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj-art-f56210c4a0b84f39abe2c92f5372d6622025-02-06T07:19:22ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X0975-15802024-07-0128442743010.4103/jisp.jisp_286_23Commensalism of Fusobacterium nucleatum - The dilemmaSangeeta NayakNishmitha D. ShettyDeepa G. KamathFusobacterium nucleatum is a Gram-negative, anaerobic bacterium that serves as a periodontal pathogen and plays a key role in linking Gram-positive and Gram-negative bacteria within the periodontal biofilm. It was shown that Fusobacterium produces significant amounts of butyric acid, which is a great source of energy for anti-inflammatory cells. On the other hand, it is associated with the destruction of periodontal structures. This bacterium can enter the blood circulation as a result of periodontal infection. It could cause numerous conditions such as halitosis, dental pulp infection, oral cancer, and systemic diseases. The present review discusses the virulence mechanisms involved in the diseases, with emphasis on its colonization, systemic dissemination, and induction of host inflammatory and tumorigenic responses. This would motivate future research on the role of this bacterium on periodontal pathology as well as its influence on the evolution of systemic diseases.https://journals.lww.com/10.4103/jisp.jisp_286_23bridging speciesfusobacterium nucleatumgram-negative bacteriaperiodontal pathogenvirulence factors |
| spellingShingle | Sangeeta Nayak Nishmitha D. Shetty Deepa G. Kamath Commensalism of Fusobacterium nucleatum - The dilemma Journal of Indian Society of Periodontology bridging species fusobacterium nucleatum gram-negative bacteria periodontal pathogen virulence factors |
| title | Commensalism of Fusobacterium nucleatum - The dilemma |
| title_full | Commensalism of Fusobacterium nucleatum - The dilemma |
| title_fullStr | Commensalism of Fusobacterium nucleatum - The dilemma |
| title_full_unstemmed | Commensalism of Fusobacterium nucleatum - The dilemma |
| title_short | Commensalism of Fusobacterium nucleatum - The dilemma |
| title_sort | commensalism of fusobacterium nucleatum the dilemma |
| topic | bridging species fusobacterium nucleatum gram-negative bacteria periodontal pathogen virulence factors |
| url | https://journals.lww.com/10.4103/jisp.jisp_286_23 |
| work_keys_str_mv | AT sangeetanayak commensalismoffusobacteriumnucleatumthedilemma AT nishmithadshetty commensalismoffusobacteriumnucleatumthedilemma AT deepagkamath commensalismoffusobacteriumnucleatumthedilemma |