Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode
Dopamine (3,4-dihydroxyphenethylamine) (DA) plays an important role in influencing emotions, pleasure sensations, concentration, pain, and coordination of body movements. However, abnormal levels of DA in the brain can lead to Parkinson’s, Alzheimer’s, or schizophrenia diseases. A biosensor is defin...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Electrical and Computer Engineering |
| Online Access: | http://dx.doi.org/10.1155/2024/7453474 |
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| author | Shindy Ayu Netania Priyanto Elly Septia Yulianti Ahmad Zakiyuddin Siti Fauziyah Rahman |
| author_facet | Shindy Ayu Netania Priyanto Elly Septia Yulianti Ahmad Zakiyuddin Siti Fauziyah Rahman |
| author_sort | Shindy Ayu Netania Priyanto |
| collection | DOAJ |
| description | Dopamine (3,4-dihydroxyphenethylamine) (DA) plays an important role in influencing emotions, pleasure sensations, concentration, pain, and coordination of body movements. However, abnormal levels of DA in the brain can lead to Parkinson’s, Alzheimer’s, or schizophrenia diseases. A biosensor is defined as an analytical tool that combines certain biological recognition components with a physical transducer. A comprehensive study was conducted to enhance the performance of DA detection by incorporating reduced graphene oxide (rGO), polypyrrole (PPy), and nickel oxide (NiO) into the glassy carbon electrode (GCE). DA levels were measured using cyclic voltammetry (CV) with a three-electrode configuration. Material characterization was evaluated by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The results obtained indicate that PPy/rGO/NiO/GCE has a detection limit of 0.195 mM and a sensitivity of 25.887 A mM−1 cm−2 for a linear range of 0.01–1 mM. |
| format | Article |
| id | doaj-art-f559b9245d2c466b92a29f68f7396b0e |
| institution | Kabale University |
| issn | 2090-0155 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Electrical and Computer Engineering |
| spelling | doaj-art-f559b9245d2c466b92a29f68f7396b0e2025-02-03T07:23:37ZengWileyJournal of Electrical and Computer Engineering2090-01552024-01-01202410.1155/2024/7453474Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon ElectrodeShindy Ayu Netania Priyanto0Elly Septia Yulianti1Ahmad Zakiyuddin2Siti Fauziyah Rahman3Department of Electrical EngineeringDepartment of Electrical EngineeringResearch Center for Biomedical EngineeringDepartment of Electrical EngineeringDopamine (3,4-dihydroxyphenethylamine) (DA) plays an important role in influencing emotions, pleasure sensations, concentration, pain, and coordination of body movements. However, abnormal levels of DA in the brain can lead to Parkinson’s, Alzheimer’s, or schizophrenia diseases. A biosensor is defined as an analytical tool that combines certain biological recognition components with a physical transducer. A comprehensive study was conducted to enhance the performance of DA detection by incorporating reduced graphene oxide (rGO), polypyrrole (PPy), and nickel oxide (NiO) into the glassy carbon electrode (GCE). DA levels were measured using cyclic voltammetry (CV) with a three-electrode configuration. Material characterization was evaluated by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The results obtained indicate that PPy/rGO/NiO/GCE has a detection limit of 0.195 mM and a sensitivity of 25.887 A mM−1 cm−2 for a linear range of 0.01–1 mM.http://dx.doi.org/10.1155/2024/7453474 |
| spellingShingle | Shindy Ayu Netania Priyanto Elly Septia Yulianti Ahmad Zakiyuddin Siti Fauziyah Rahman Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode Journal of Electrical and Computer Engineering |
| title | Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode |
| title_full | Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode |
| title_fullStr | Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode |
| title_full_unstemmed | Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode |
| title_short | Amperometric Biosensor Detecting Dopamine Based on Polypyrrole/Reduced Graphene Oxide/Nickel Oxide/Glassy Carbon Electrode |
| title_sort | amperometric biosensor detecting dopamine based on polypyrrole reduced graphene oxide nickel oxide glassy carbon electrode |
| url | http://dx.doi.org/10.1155/2024/7453474 |
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