EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson’s disease

EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson’s disease

Abstract Parkinson’s disease (PD), characterized by α-synuclein accumulation in dopaminergic neurons, is a common neurodegenerative disorder. Recent findings highlight DNAJB1 as a crucial factor in the disaggregation of α-synuclein fibrils in vitro, yet the underlying mechanisms and regulatory proce...

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Bibliographic Details
Main Authors: Yun-Yu Huang, Sue-Jane Lin, Wei-Yu Chiang, Yuan-Teng Chang, Chan-Chih Yang, Chia-Yu Liao, Ya-Lan Chang, Chin-Hsien Lin, Shu-Chun Teng
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01006-y
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