Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis

Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis

Abstract Richter syndrome (RS), characterized by aggressive lymphoma arising from chronic lymphocytic leukaemia (CLL), presents a poor response to treatment and grim prognosis. To elucidate RS mechanisms, paired samples from a patient with DLBCL-RS were subjected to single-cell RNA sequencing (scRNA...

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Bibliographic Details
Main Authors: Heng Li, Cheng Xing, Ji Li, Yihao Zhan, Ming Luo, Peilong Wang, Yue Sheng, Hongling Peng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biomarker Research
Subjects:
Richter syndrome
Chronic lymphocytic leukaemia
scRNA-seq
Chromosome conformation capture sequencing
Hi-C
cAMP-mediated signalling
Online Access:https://doi.org/10.1186/s40364-024-00723-5
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