Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study)
To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concer...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2017/4047392 |
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| author | Maria-Rosario Luquin Jaime Kulisevsky Pablo Martinez-Martin Pablo Mir Eduardo S. Tolosa |
| author_facet | Maria-Rosario Luquin Jaime Kulisevsky Pablo Martinez-Martin Pablo Mir Eduardo S. Tolosa |
| author_sort | Maria-Rosario Luquin |
| collection | DOAJ |
| description | To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the first-round, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtained were incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders. Review of results from the second-round led to a classification of symptoms as indicative of “definitive,” “probable,” and “possible” APD. This classification was confirmed by 149 previous participating neurologists in a third-round, where 92% completely or very much agreed with the classification. Definitive symptoms of APD included disability requiring help for the activities of daily living, presence of motor fluctuations with limitations to perform basic activities of daily living without help, severe dysphagia, recurrent falls, and dementia. These results will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition. |
| format | Article |
| id | doaj-art-f53a21308dfb4fb9989eb9d6da83a8a7 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-f53a21308dfb4fb9989eb9d6da83a8a72025-02-03T06:13:22ZengWileyParkinson's Disease2090-80832042-00802017-01-01201710.1155/2017/40473924047392Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study)Maria-Rosario Luquin0Jaime Kulisevsky1Pablo Martinez-Martin2Pablo Mir3Eduardo S. Tolosa4Department of Neurology, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, SpainDepartment of Neurology, Movement Disorders Unit, Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Universitat Oberta de Catalunya (UOC), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, SpainUnidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, SpainTo date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on the definition of APD, we performed a prospective, multicenter, Spanish nationwide, 3-round Delphi study (CEPA study). An ad hoc questionnaire was designed with 33 questions concerning the relevance of several clinical features for APD diagnosis. In the first-round, 240 neurologists of the Spanish Movement Disorders Group participated in the study. The results obtained were incorporated into the questionnaire and both, results and questionnaire, were sent out to and fulfilled by 26 experts in Movement Disorders. Review of results from the second-round led to a classification of symptoms as indicative of “definitive,” “probable,” and “possible” APD. This classification was confirmed by 149 previous participating neurologists in a third-round, where 92% completely or very much agreed with the classification. Definitive symptoms of APD included disability requiring help for the activities of daily living, presence of motor fluctuations with limitations to perform basic activities of daily living without help, severe dysphagia, recurrent falls, and dementia. These results will help neurologists to identify some key factors in APD diagnosis, thus allowing users to categorize the patients for a homogeneous recognition of this condition.http://dx.doi.org/10.1155/2017/4047392 |
| spellingShingle | Maria-Rosario Luquin Jaime Kulisevsky Pablo Martinez-Martin Pablo Mir Eduardo S. Tolosa Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study) Parkinson's Disease |
| title | Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study) |
| title_full | Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study) |
| title_fullStr | Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study) |
| title_full_unstemmed | Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study) |
| title_short | Consensus on the Definition of Advanced Parkinson’s Disease: A Neurologists-Based Delphi Study (CEPA Study) |
| title_sort | consensus on the definition of advanced parkinson s disease a neurologists based delphi study cepa study |
| url | http://dx.doi.org/10.1155/2017/4047392 |
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