Simultaneous and sequential enzymatic cascades for asymmetric synthesis of chiral beta-hydroxyamide derivatives promoted by alcohol dehydrogenases and nitrile hydratases
Asymmetric synthesis of optically pure (S)-3-hydroxy-3-phenylpropanamide derivatives from o-, m- and p-substituted benzoylacetonitrile was achieved by two enzymatic one-pot protocols, the simultaneous and the sequential two-step linear cascade promoted by alcohol dehydrogenase (ADH) and nitrile hydr...
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| Main Authors: | Everton A. Tordato, Shirley A. Castilho, Humberto M. S. Milagre, Cintia D. F. Milagre |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | Green Chemistry Letters and Reviews |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2024.2343707 |
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