Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis
Affective disorders, such as anxiety and depression, are common comorbidities associated with chronic insomnia disorder (CID). However, the underlying neural mechanisms of these comorbidities are still not clear. The present study is aimed at investigating structural changes in the amygdala of CID p...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/8549237 |
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| author | Liang Gong Tianzhi Liao Duan Liu Qiuhua Luo Ronghua Xu Qun Huang Bei Zhang Fen Feng Chuantao Zhang |
| author_facet | Liang Gong Tianzhi Liao Duan Liu Qiuhua Luo Ronghua Xu Qun Huang Bei Zhang Fen Feng Chuantao Zhang |
| author_sort | Liang Gong |
| collection | DOAJ |
| description | Affective disorders, such as anxiety and depression, are common comorbidities associated with chronic insomnia disorder (CID). However, the underlying neural mechanisms of these comorbidities are still not clear. The present study is aimed at investigating structural changes in the amygdala of CID patients using surface-based shape analysis. A total of 65 medication-naive patients with CID and 55 healthy controls (HCs) matched for age, sex, and years of education were enrolled in this study and were subjected to structural magnetic resonance imaging (MRI). The Oxford Centre for Functional MRI of the Brain (FMRIB) created an Integrated Registration and Segmentation Tool (FIRST) that was employed in this study to assess the volumetric and surface alterations in patients with CID. Shape correlations between the amygdala and clinical features were also analyzed. Atrophic changes in the amygdala were observed at the local level, not for the entire amygdala volume. The left atrophic changes in the amygdala were in the superficial and basolateral nuclei while right atrophic changes were in the basolateral nuclei in CID patients. Insomnia severity was associated with the centromedial right amygdala while anxiety was linked with the basolateral nuclei. These findings indicate localized amygdala atrophy in CID. Separate amygdala regions are associated with insomnia and anxiety in CID. This evidence helps elucidate the neural mechanisms underlying the bidirectional relationship between insomnia and anxiety. |
| format | Article |
| id | doaj-art-f51649c6df1b44f2a8a1f36e4a7ef6b6 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-f51649c6df1b44f2a8a1f36e4a7ef6b62025-08-20T03:25:22ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/85492378549237Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape AnalysisLiang Gong0Tianzhi Liao1Duan Liu2Qiuhua Luo3Ronghua Xu4Qun Huang5Bei Zhang6Fen Feng7Chuantao Zhang8Department of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, ChinaDepartment of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, ChinaDepartment of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, ChinaDepartment of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, ChinaDepartment of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, ChinaDepartment of Neurology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, ChinaDepartment of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, ChinaAffective disorders, such as anxiety and depression, are common comorbidities associated with chronic insomnia disorder (CID). However, the underlying neural mechanisms of these comorbidities are still not clear. The present study is aimed at investigating structural changes in the amygdala of CID patients using surface-based shape analysis. A total of 65 medication-naive patients with CID and 55 healthy controls (HCs) matched for age, sex, and years of education were enrolled in this study and were subjected to structural magnetic resonance imaging (MRI). The Oxford Centre for Functional MRI of the Brain (FMRIB) created an Integrated Registration and Segmentation Tool (FIRST) that was employed in this study to assess the volumetric and surface alterations in patients with CID. Shape correlations between the amygdala and clinical features were also analyzed. Atrophic changes in the amygdala were observed at the local level, not for the entire amygdala volume. The left atrophic changes in the amygdala were in the superficial and basolateral nuclei while right atrophic changes were in the basolateral nuclei in CID patients. Insomnia severity was associated with the centromedial right amygdala while anxiety was linked with the basolateral nuclei. These findings indicate localized amygdala atrophy in CID. Separate amygdala regions are associated with insomnia and anxiety in CID. This evidence helps elucidate the neural mechanisms underlying the bidirectional relationship between insomnia and anxiety.http://dx.doi.org/10.1155/2019/8549237 |
| spellingShingle | Liang Gong Tianzhi Liao Duan Liu Qiuhua Luo Ronghua Xu Qun Huang Bei Zhang Fen Feng Chuantao Zhang Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis Neural Plasticity |
| title | Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis |
| title_full | Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis |
| title_fullStr | Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis |
| title_full_unstemmed | Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis |
| title_short | Amygdala Changes in Chronic Insomnia and Their Association with Sleep and Anxiety Symptoms: Insight from Shape Analysis |
| title_sort | amygdala changes in chronic insomnia and their association with sleep and anxiety symptoms insight from shape analysis |
| url | http://dx.doi.org/10.1155/2019/8549237 |
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