Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease
Leishmaniasis is a group of neglected diseases whose clinical manifestations depend on factors from the host and the pathogen. It is an important public health problem worldwide caused by the protozoan parasite from the Leishmania genus. Cutaneous Leishmaniasis (CL) is the most frequent form of this...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/3967436 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553370845446144 |
|---|---|
| author | Daniel Feijó Rafael Tibúrcio Mariana Ampuero Cláudia Brodskyn Natalia Tavares |
| author_facet | Daniel Feijó Rafael Tibúrcio Mariana Ampuero Cláudia Brodskyn Natalia Tavares |
| author_sort | Daniel Feijó |
| collection | DOAJ |
| description | Leishmaniasis is a group of neglected diseases whose clinical manifestations depend on factors from the host and the pathogen. It is an important public health problem worldwide caused by the protozoan parasite from the Leishmania genus. Cutaneous Leishmaniasis (CL) is the most frequent form of this disease transmitted by the bite of an infected sandfly into the host skin. The parasites can be uptook and/or recognized by macrophages, neutrophils, and/or dendritic cells (DCs). Initially, DCs were described to play a protective role in activating the immune response against Leishmania parasites. However, several reports showed a dichotomic role of DCs in modulating the host immune response to susceptibility or resistance in CL. In this review, we discuss (1) the interactions between DCs and parasites from different species of Leishmania and (2) the crosstalk of DCs and other cells during CL infection. The complexity of these interactions profoundly affects the adaptive immune response and, consequently, the disease outcome, especially from Leishmania species of the New World. |
| format | Article |
| id | doaj-art-f516486d30c2487191c089e4253e1a98 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f516486d30c2487191c089e4253e1a982025-02-03T05:54:17ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/39674363967436Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex DiseaseDaniel Feijó0Rafael Tibúrcio1Mariana Ampuero2Cláudia Brodskyn3Natalia Tavares4Centro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz (CPqGM), 40296-710 Salvador, BA, BrazilLeishmaniasis is a group of neglected diseases whose clinical manifestations depend on factors from the host and the pathogen. It is an important public health problem worldwide caused by the protozoan parasite from the Leishmania genus. Cutaneous Leishmaniasis (CL) is the most frequent form of this disease transmitted by the bite of an infected sandfly into the host skin. The parasites can be uptook and/or recognized by macrophages, neutrophils, and/or dendritic cells (DCs). Initially, DCs were described to play a protective role in activating the immune response against Leishmania parasites. However, several reports showed a dichotomic role of DCs in modulating the host immune response to susceptibility or resistance in CL. In this review, we discuss (1) the interactions between DCs and parasites from different species of Leishmania and (2) the crosstalk of DCs and other cells during CL infection. The complexity of these interactions profoundly affects the adaptive immune response and, consequently, the disease outcome, especially from Leishmania species of the New World.http://dx.doi.org/10.1155/2016/3967436 |
| spellingShingle | Daniel Feijó Rafael Tibúrcio Mariana Ampuero Cláudia Brodskyn Natalia Tavares Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease Journal of Immunology Research |
| title | Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease |
| title_full | Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease |
| title_fullStr | Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease |
| title_full_unstemmed | Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease |
| title_short | Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease |
| title_sort | dendritic cells and leishmania infection adding layers of complexity to a complex disease |
| url | http://dx.doi.org/10.1155/2016/3967436 |
| work_keys_str_mv | AT danielfeijo dendriticcellsandleishmaniainfectionaddinglayersofcomplexitytoacomplexdisease AT rafaeltiburcio dendriticcellsandleishmaniainfectionaddinglayersofcomplexitytoacomplexdisease AT marianaampuero dendriticcellsandleishmaniainfectionaddinglayersofcomplexitytoacomplexdisease AT claudiabrodskyn dendriticcellsandleishmaniainfectionaddinglayersofcomplexitytoacomplexdisease AT nataliatavares dendriticcellsandleishmaniainfectionaddinglayersofcomplexitytoacomplexdisease |