New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis
Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin-angiotensin system (RAS). The discovery of the angiotensin-converting enzyme homologue ACE2 revealed important metabolic pathways involved in the Ang-(1–7) synthesis. This enzyme can form Ang-(1–7) from Ang II...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/147825 |
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| author | Anderson J. Ferreira Tatiane M. Murça Rodrigo A. Fraga-Silva Carlos Henrique Castro Mohan K. Raizada Robson A. S. Santos |
| author_facet | Anderson J. Ferreira Tatiane M. Murça Rodrigo A. Fraga-Silva Carlos Henrique Castro Mohan K. Raizada Robson A. S. Santos |
| author_sort | Anderson J. Ferreira |
| collection | DOAJ |
| description | Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin-angiotensin system (RAS). The discovery of the angiotensin-converting enzyme homologue ACE2 revealed important metabolic pathways involved in the Ang-(1–7) synthesis. This enzyme can form Ang-(1–7) from Ang II or less efficiently through hydrolysis of Ang I to Ang-(1–9) with subsequent Ang-(1–7) formation. Additionally, it is well established that the G protein-coupled receptor Mas is a functional ligand site for Ang-(1–7). The axis formed by ACE2/Ang-(1–7)/Mas represents an endogenous counter regulatory pathway within the RAS whose actions are opposite to the vasoconstrictor/proliferative arm of the RAS constituted by ACE/Ang II/AT1 receptor. In this review we will discuss recent findings concerning the biological role of the ACE2/Ang-(1–7)/Mas arm in the cardiovascular and pulmonary system. Also, we will highlight the initiatives to develop potential therapeutic strategies based on this axis. |
| format | Article |
| id | doaj-art-f513b43cb05f4b57ba69243db5977280 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-f513b43cb05f4b57ba69243db59772802025-02-03T01:12:07ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/147825147825New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor AxisAnderson J. Ferreira0Tatiane M. Murça1Rodrigo A. Fraga-Silva2Carlos Henrique Castro3Mohan K. Raizada4Robson A. S. Santos5Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 31.270-901 Belo Horizonte, MG, BrazilDepartment of Physiology Sciences, Federal University of Goiás, 74.001-970 Goiânia, GO, BrazilDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, 32.610 Gainesville, FL, USADepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 31.270-901 Belo Horizonte, MG, BrazilAngiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin-angiotensin system (RAS). The discovery of the angiotensin-converting enzyme homologue ACE2 revealed important metabolic pathways involved in the Ang-(1–7) synthesis. This enzyme can form Ang-(1–7) from Ang II or less efficiently through hydrolysis of Ang I to Ang-(1–9) with subsequent Ang-(1–7) formation. Additionally, it is well established that the G protein-coupled receptor Mas is a functional ligand site for Ang-(1–7). The axis formed by ACE2/Ang-(1–7)/Mas represents an endogenous counter regulatory pathway within the RAS whose actions are opposite to the vasoconstrictor/proliferative arm of the RAS constituted by ACE/Ang II/AT1 receptor. In this review we will discuss recent findings concerning the biological role of the ACE2/Ang-(1–7)/Mas arm in the cardiovascular and pulmonary system. Also, we will highlight the initiatives to develop potential therapeutic strategies based on this axis.http://dx.doi.org/10.1155/2012/147825 |
| spellingShingle | Anderson J. Ferreira Tatiane M. Murça Rodrigo A. Fraga-Silva Carlos Henrique Castro Mohan K. Raizada Robson A. S. Santos New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis International Journal of Hypertension |
| title | New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis |
| title_full | New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis |
| title_fullStr | New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis |
| title_full_unstemmed | New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis |
| title_short | New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis |
| title_sort | new cardiovascular and pulmonary therapeutic strategies based on the angiotensin converting enzyme 2 angiotensin 1 7 mas receptor axis |
| url | http://dx.doi.org/10.1155/2012/147825 |
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