Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats
Objective. The effects of low-intensity 630 nm semiconductor laser irradiation at 3.6 J/cm2 (LISL) on wound healing in diabetic rats were studied in this paper. Methods. 36 diabetic rats with dorsal cutaneous excisional wounds were divided into three LISL groups and a control group randomly. The thr...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2012/838496 |
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| _version_ | 1832558563409526784 |
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| author | Hui Ma Ying-xin Li Hong-li Chen Mei-ling Kang Timon Cheng-Yi Liu |
| author_facet | Hui Ma Ying-xin Li Hong-li Chen Mei-ling Kang Timon Cheng-Yi Liu |
| author_sort | Hui Ma |
| collection | DOAJ |
| description | Objective. The effects of low-intensity 630 nm semiconductor laser irradiation at 3.6 J/cm2 (LISL) on wound healing in diabetic rats were studied in this paper. Methods. 36 diabetic rats with dorsal cutaneous excisional wounds were divided into three LISL groups and a control group randomly. The three LISL groups were irradiated with LISL at 5, 10, and 20 mW/cm2 five times a week for two weeks, respectively. The process of wound healing was assessed by assessing blood glucose, calculating percentage of wound closure, histopathological evaluation, and immunohistochemical quantification. Results. Blood glucose of all groups remained at similar levels throughout the experiment. LISL could obviously promote wound contraction, fibroblasts proliferation, and collagen synthesis, alter bFGF and TGF-β1 expression, and reduce inflammatory reaction in the early and middle phases of chronic wound-healing process. However, LISL could not shorten cicatrization time, and the treatment effects were not sensitive to illuminate parameters in the later phase of the experiment. Conclusions. LISL might have auxiliary effects in the early and middle phases of wound healing in STZ-induced diabetic rats, but the reciprocity rule might not hold. The wound-healing process of early-phase diabetes rats shows typical characteristics of self-limited disease. |
| format | Article |
| id | doaj-art-f50a78fcec9b41feb670e641d21e06c3 |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-f50a78fcec9b41feb670e641d21e06c32025-02-03T01:32:06ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2012-01-01201210.1155/2012/838496838496Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic RatsHui Ma0Ying-xin Li1Hong-li Chen2Mei-ling Kang3Timon Cheng-Yi Liu4School of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, ChinaTianjin Laser Medical Technology Engineering Center, Tianjin 300350, ChinaSchool of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, ChinaSchool of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, ChinaLaboratory of Laser Sports Medicine, South China Normal University, Guangzhou 510006, ChinaObjective. The effects of low-intensity 630 nm semiconductor laser irradiation at 3.6 J/cm2 (LISL) on wound healing in diabetic rats were studied in this paper. Methods. 36 diabetic rats with dorsal cutaneous excisional wounds were divided into three LISL groups and a control group randomly. The three LISL groups were irradiated with LISL at 5, 10, and 20 mW/cm2 five times a week for two weeks, respectively. The process of wound healing was assessed by assessing blood glucose, calculating percentage of wound closure, histopathological evaluation, and immunohistochemical quantification. Results. Blood glucose of all groups remained at similar levels throughout the experiment. LISL could obviously promote wound contraction, fibroblasts proliferation, and collagen synthesis, alter bFGF and TGF-β1 expression, and reduce inflammatory reaction in the early and middle phases of chronic wound-healing process. However, LISL could not shorten cicatrization time, and the treatment effects were not sensitive to illuminate parameters in the later phase of the experiment. Conclusions. LISL might have auxiliary effects in the early and middle phases of wound healing in STZ-induced diabetic rats, but the reciprocity rule might not hold. The wound-healing process of early-phase diabetes rats shows typical characteristics of self-limited disease.http://dx.doi.org/10.1155/2012/838496 |
| spellingShingle | Hui Ma Ying-xin Li Hong-li Chen Mei-ling Kang Timon Cheng-Yi Liu Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats International Journal of Photoenergy |
| title | Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats |
| title_full | Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats |
| title_fullStr | Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats |
| title_full_unstemmed | Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats |
| title_short | Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats |
| title_sort | effects of low intensity laser irradiation on wound healing in diabetic rats |
| url | http://dx.doi.org/10.1155/2012/838496 |
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