Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges
mRNA vaccines offer groundbreaking technological advantages and broad application potential. Their rapid advancement, particularly during the COVID-19 pandemic, is the result of decades of research and numerous technological breakthroughs. These discoveries build upon each other, forming dense, inte...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2454078 |
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| author | Ting Zhang Zhongquan Jian Juan Chen Dongzi Xu Xiaoyi Yang Yan Lu Shu Yan Lizi Pan Qingqiang Wu Zhaolian Ouyang |
| author_facet | Ting Zhang Zhongquan Jian Juan Chen Dongzi Xu Xiaoyi Yang Yan Lu Shu Yan Lizi Pan Qingqiang Wu Zhaolian Ouyang |
| author_sort | Ting Zhang |
| collection | DOAJ |
| description | mRNA vaccines offer groundbreaking technological advantages and broad application potential. Their rapid advancement, particularly during the COVID-19 pandemic, is the result of decades of research and numerous technological breakthroughs. These discoveries build upon each other, forming dense, interconnected networks of progress. Studying the technological development paths of mRNA vaccines is therefore essential. Main path analysis (MPA) is particularly effective for mapping out development trajectories within complex and interconnected networks, which serves as a powerful tool for identifying key nodes and innovations. This study introduces a novel approach to extracting main paths from a patent citation network in the mRNA vaccine field. Initially, we shielded edges connecting the origin and terminus patents. Subsequently, we extracted the main paths from intermediate patents, and then, we reintegrated the edges connecting the origin and terminus patents based on the citation relationships, resulting in a comprehensive extraction of the main paths. The research findings indicate a consistency among the global main paths, global key-route main paths, local forward main paths, and local key-route main paths within the mRNA vaccine field. The patents on the main paths predominantly focus on nucleic acid modifications and delivery systems. The local backward main paths identify a greater number of patents, especially those related to litigation, offering a richer and more diverse set of technological insights. This study significantly advances the methodology of MPA, with the innovative shielding technique offering a fresh perspective for navigating complex networks and providing a deeper understanding of technological development in the mRNA vaccine domain. |
| format | Article |
| id | doaj-art-f4f5f6163f5f496ea84abf805ba1bb69 |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-f4f5f6163f5f496ea84abf805ba1bb692025-01-22T08:22:00ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2454078Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edgesTing Zhang0Zhongquan Jian1Juan Chen2Dongzi Xu3Xiaoyi Yang4Yan Lu5Shu Yan6Lizi Pan7Qingqiang Wu8Zhaolian Ouyang9Institute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaInstitute of Artificial Intelligence, Xiamen University, Xiamen, Fujian, ChinaInstitute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaInstitute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaInstitute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaInstitute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaInstitute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaInstitute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaXiamen University, Xiamen, Fujian, ChinaInstitute of Medical Information & Library, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinamRNA vaccines offer groundbreaking technological advantages and broad application potential. Their rapid advancement, particularly during the COVID-19 pandemic, is the result of decades of research and numerous technological breakthroughs. These discoveries build upon each other, forming dense, interconnected networks of progress. Studying the technological development paths of mRNA vaccines is therefore essential. Main path analysis (MPA) is particularly effective for mapping out development trajectories within complex and interconnected networks, which serves as a powerful tool for identifying key nodes and innovations. This study introduces a novel approach to extracting main paths from a patent citation network in the mRNA vaccine field. Initially, we shielded edges connecting the origin and terminus patents. Subsequently, we extracted the main paths from intermediate patents, and then, we reintegrated the edges connecting the origin and terminus patents based on the citation relationships, resulting in a comprehensive extraction of the main paths. The research findings indicate a consistency among the global main paths, global key-route main paths, local forward main paths, and local key-route main paths within the mRNA vaccine field. The patents on the main paths predominantly focus on nucleic acid modifications and delivery systems. The local backward main paths identify a greater number of patents, especially those related to litigation, offering a richer and more diverse set of technological insights. This study significantly advances the methodology of MPA, with the innovative shielding technique offering a fresh perspective for navigating complex networks and providing a deeper understanding of technological development in the mRNA vaccine domain.https://www.tandfonline.com/doi/10.1080/21645515.2025.2454078mRNA vaccinemain path analysis (MPA)patent citation networkintermediate patentsshielding edgessearch path link count (SPLC) |
| spellingShingle | Ting Zhang Zhongquan Jian Juan Chen Dongzi Xu Xiaoyi Yang Yan Lu Shu Yan Lizi Pan Qingqiang Wu Zhaolian Ouyang Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges Human Vaccines & Immunotherapeutics mRNA vaccine main path analysis (MPA) patent citation network intermediate patents shielding edges search path link count (SPLC) |
| title | Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges |
| title_full | Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges |
| title_fullStr | Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges |
| title_full_unstemmed | Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges |
| title_short | Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges |
| title_sort | efficiency enhancement in main path extraction in mrna vaccine field a novel approach leveraging intermediate patents with shielding origin and terminus patent edges |
| topic | mRNA vaccine main path analysis (MPA) patent citation network intermediate patents shielding edges search path link count (SPLC) |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2454078 |
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