Cancer Cachexia: Mechanisms and Clinical Implications
Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients. It involves multiple pathways: procachectic and proinflammatory signals...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/601434 |
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| author | Claire L. Donohoe Aoife M. Ryan John V. Reynolds |
| author_facet | Claire L. Donohoe Aoife M. Ryan John V. Reynolds |
| author_sort | Claire L. Donohoe |
| collection | DOAJ |
| description | Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients. It involves multiple pathways: procachectic and proinflammatory signals from tumour cells, systemic inflammation in the host, and widespread metabolic changes (increased resting energy expenditure and alterations in metabolism of protein, fat, and carbohydrate). Whether it is primarily driven by the tumour or as a result of the host response to the tumour has yet to be fully elucidated. Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully. Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has been slow progress in identifying therapeutic agents and trialling them in the clinical setting. Understanding the complex interplay of tumour and host factors will uncover new therapeutic targets. |
| format | Article |
| id | doaj-art-f4e32a5b4de44529bf693ec96af9f7bc |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f4e32a5b4de44529bf693ec96af9f7bc2025-02-03T01:02:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2011-01-01201110.1155/2011/601434601434Cancer Cachexia: Mechanisms and Clinical ImplicationsClaire L. Donohoe0Aoife M. Ryan1John V. Reynolds2Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, St James’ Hospital, Dublin 8, IrelandDepartment of Nutrition, Food Studies and Public Health, New York University, New York, NY 10003, USADepartment of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin, St James’ Hospital, Dublin 8, IrelandCachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients. It involves multiple pathways: procachectic and proinflammatory signals from tumour cells, systemic inflammation in the host, and widespread metabolic changes (increased resting energy expenditure and alterations in metabolism of protein, fat, and carbohydrate). Whether it is primarily driven by the tumour or as a result of the host response to the tumour has yet to be fully elucidated. Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully. Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has been slow progress in identifying therapeutic agents and trialling them in the clinical setting. Understanding the complex interplay of tumour and host factors will uncover new therapeutic targets.http://dx.doi.org/10.1155/2011/601434 |
| spellingShingle | Claire L. Donohoe Aoife M. Ryan John V. Reynolds Cancer Cachexia: Mechanisms and Clinical Implications Gastroenterology Research and Practice |
| title | Cancer Cachexia: Mechanisms and Clinical Implications |
| title_full | Cancer Cachexia: Mechanisms and Clinical Implications |
| title_fullStr | Cancer Cachexia: Mechanisms and Clinical Implications |
| title_full_unstemmed | Cancer Cachexia: Mechanisms and Clinical Implications |
| title_short | Cancer Cachexia: Mechanisms and Clinical Implications |
| title_sort | cancer cachexia mechanisms and clinical implications |
| url | http://dx.doi.org/10.1155/2011/601434 |
| work_keys_str_mv | AT claireldonohoe cancercachexiamechanismsandclinicalimplications AT aoifemryan cancercachexiamechanismsandclinicalimplications AT johnvreynolds cancercachexiamechanismsandclinicalimplications |