The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and Pemphigus
With a growing awareness of climate change, air pollution has emerged as an important contributor to the development and exacerbation of inflammatory skin conditions. However, the effect of air pollution on immunobullous disease activity is unknown. In this study, we performed a retrospective cohort...
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Elsevier
2025-05-01
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| Series: | JID Innovations |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667026724000821 |
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| author | Ron Feldman Emily F. Cole |
| author_facet | Ron Feldman Emily F. Cole |
| author_sort | Ron Feldman |
| collection | DOAJ |
| description | With a growing awareness of climate change, air pollution has emerged as an important contributor to the development and exacerbation of inflammatory skin conditions. However, the effect of air pollution on immunobullous disease activity is unknown. In this study, we performed a retrospective cohort study of 115 patients with bullous pemphigoid and 152 patients with pemphigus from a university-based specialty clinic in the Southeastern United States. We compared standardized disease activity measures with inhalable particulate matter (particulate matter ≤2.5, particulate matter ≤10), ozone, atmospheric pollutants (sulphur dioxide, carbon monoxide, nitrogen dioxide), and air quality index. Results demonstrated small but statistically significant associations between Bullous Pemphigoid Disease Area Index total activity score and several variables (particulate matter ≤2.5, sulphur dioxide, and air quality index). In addition, there were small but significant negative correlations between ozone and bullous pemphigoid disease area index pruritus score as well as carbon monoxide and pemphigus disease area index score. This study suggests that air pollution may impact disease activity in bullous pemphigoid to a greater extent than pemphigus. Future studies should be aimed at identifying potential mechanisms for this association. |
| format | Article |
| id | doaj-art-f4dd288de5cc42bbaf4363a711019aad |
| institution | Kabale University |
| issn | 2667-0267 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
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| series | JID Innovations |
| spelling | doaj-art-f4dd288de5cc42bbaf4363a711019aad2025-01-19T06:26:51ZengElsevierJID Innovations2667-02672025-05-0153100334The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and PemphigusRon Feldman0Emily F. Cole1Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USADepartment of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA; Correspondence: Emily F. Cole, Department of Dermatology, Washington University School of Medicine, 660 South Euclid Avenue, MSC 8123-29-10014, St. Louis, Missouri 63110, USA.With a growing awareness of climate change, air pollution has emerged as an important contributor to the development and exacerbation of inflammatory skin conditions. However, the effect of air pollution on immunobullous disease activity is unknown. In this study, we performed a retrospective cohort study of 115 patients with bullous pemphigoid and 152 patients with pemphigus from a university-based specialty clinic in the Southeastern United States. We compared standardized disease activity measures with inhalable particulate matter (particulate matter ≤2.5, particulate matter ≤10), ozone, atmospheric pollutants (sulphur dioxide, carbon monoxide, nitrogen dioxide), and air quality index. Results demonstrated small but statistically significant associations between Bullous Pemphigoid Disease Area Index total activity score and several variables (particulate matter ≤2.5, sulphur dioxide, and air quality index). In addition, there were small but significant negative correlations between ozone and bullous pemphigoid disease area index pruritus score as well as carbon monoxide and pemphigus disease area index score. This study suggests that air pollution may impact disease activity in bullous pemphigoid to a greater extent than pemphigus. Future studies should be aimed at identifying potential mechanisms for this association.http://www.sciencedirect.com/science/article/pii/S2667026724000821Air qualityClimate changePemphigoidPemphigusPollution |
| spellingShingle | Ron Feldman Emily F. Cole The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and Pemphigus JID Innovations Air quality Climate change Pemphigoid Pemphigus Pollution |
| title | The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and Pemphigus |
| title_full | The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and Pemphigus |
| title_fullStr | The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and Pemphigus |
| title_full_unstemmed | The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and Pemphigus |
| title_short | The Impact of Air Pollution on Disease Activity in Bullous Pemphigoid and Pemphigus |
| title_sort | impact of air pollution on disease activity in bullous pemphigoid and pemphigus |
| topic | Air quality Climate change Pemphigoid Pemphigus Pollution |
| url | http://www.sciencedirect.com/science/article/pii/S2667026724000821 |
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