RUNX2 enhances bladder cancer progression by promoting glutamine metabolism
Bladder cancer is a prevalent malignancy within the urinary system. Prior research has suggested that glutamine metabolism plays a crucial role in driving bladder cancer progression. However, the precise molecular mechanism governing glutamine metabolism in bladder cancer is still inadequately under...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558624001611 |
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| author | Zhigang Huang Bin Liu Xiaoju Li Chenghua Jin Quansen Hu Zhiwei Zhao Yimin Sun Qian Wang |
| author_facet | Zhigang Huang Bin Liu Xiaoju Li Chenghua Jin Quansen Hu Zhiwei Zhao Yimin Sun Qian Wang |
| author_sort | Zhigang Huang |
| collection | DOAJ |
| description | Bladder cancer is a prevalent malignancy within the urinary system. Prior research has suggested that glutamine metabolism plays a crucial role in driving bladder cancer progression. However, the precise molecular mechanism governing glutamine metabolism in bladder cancer is still inadequately understood. The research revealed a significant correlation between high levels of RUNX2 and SLC7A6 and advanced clinical stage, as well as poor prognosis, in bladder cancer patients. Furthermore, manipulating the levels of RUNX2 through overexpression or silencing demonstrated a significant impact on glutamine and bladder cancer progression. Mechanically, RUNX2 regulates the transcription of SLC7A6, resulting in enhanced glutamine metabolism and promoting the progression of bladder cancer. Overall, this research affirms the crucial function of RUNX2 as a key transcription factor to promoting glutamine and cancer development through modulation of SLC7A6. Targeting RUNX2 could represent a promising therapeutic approach for addressing aberrant glutamine metabolism in bladder cancer. |
| format | Article |
| id | doaj-art-f4c8d3ec8e0d4515b83086fd18cbf40a |
| institution | Kabale University |
| issn | 1476-5586 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj-art-f4c8d3ec8e0d4515b83086fd18cbf40a2025-02-03T04:16:36ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862025-02-0160101120RUNX2 enhances bladder cancer progression by promoting glutamine metabolismZhigang Huang0Bin Liu1Xiaoju Li2Chenghua Jin3Quansen Hu4Zhiwei Zhao5Yimin Sun6Qian Wang7Department of Urology, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaDepartment of Urology, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaDepartment of Urology, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaDepartment of Urology, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaDepartment of Urology, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaCorresponding author.; Department of Urology, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, China; Department of Traditional Chinese Medicine, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, China; Department of Oncology, The First Affiliated Hospital of Yangtze University, JingZhou, Hubei Province, ChinaBladder cancer is a prevalent malignancy within the urinary system. Prior research has suggested that glutamine metabolism plays a crucial role in driving bladder cancer progression. However, the precise molecular mechanism governing glutamine metabolism in bladder cancer is still inadequately understood. The research revealed a significant correlation between high levels of RUNX2 and SLC7A6 and advanced clinical stage, as well as poor prognosis, in bladder cancer patients. Furthermore, manipulating the levels of RUNX2 through overexpression or silencing demonstrated a significant impact on glutamine and bladder cancer progression. Mechanically, RUNX2 regulates the transcription of SLC7A6, resulting in enhanced glutamine metabolism and promoting the progression of bladder cancer. Overall, this research affirms the crucial function of RUNX2 as a key transcription factor to promoting glutamine and cancer development through modulation of SLC7A6. Targeting RUNX2 could represent a promising therapeutic approach for addressing aberrant glutamine metabolism in bladder cancer.http://www.sciencedirect.com/science/article/pii/S1476558624001611RUNX2Bladder cancerGlutamine metabolism |
| spellingShingle | Zhigang Huang Bin Liu Xiaoju Li Chenghua Jin Quansen Hu Zhiwei Zhao Yimin Sun Qian Wang RUNX2 enhances bladder cancer progression by promoting glutamine metabolism Neoplasia: An International Journal for Oncology Research RUNX2 Bladder cancer Glutamine metabolism |
| title | RUNX2 enhances bladder cancer progression by promoting glutamine metabolism |
| title_full | RUNX2 enhances bladder cancer progression by promoting glutamine metabolism |
| title_fullStr | RUNX2 enhances bladder cancer progression by promoting glutamine metabolism |
| title_full_unstemmed | RUNX2 enhances bladder cancer progression by promoting glutamine metabolism |
| title_short | RUNX2 enhances bladder cancer progression by promoting glutamine metabolism |
| title_sort | runx2 enhances bladder cancer progression by promoting glutamine metabolism |
| topic | RUNX2 Bladder cancer Glutamine metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S1476558624001611 |
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