Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction
Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/438125 |
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| _version_ | 1832555823546499072 |
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| author | E. W. Yates A. Rupani G. T. Foley W. S. Khan S. Cartmell S. J. Anand |
| author_facet | E. W. Yates A. Rupani G. T. Foley W. S. Khan S. Cartmell S. J. Anand |
| author_sort | E. W. Yates |
| collection | DOAJ |
| description | Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. We evaluate the current literature on ligament tissue engineering and its role in anterior cruciate ligament reconstruction. |
| format | Article |
| id | doaj-art-f4c5d803191d4f98bae8b449dc953a3e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f4c5d803191d4f98bae8b449dc953a3e2025-02-03T05:47:12ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/438125438125Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament ReconstructionE. W. Yates0A. Rupani1G. T. Foley2W. S. Khan3S. Cartmell4S. J. Anand5Department of Trauma and Orthopaedics, Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, SK2 7JE, UKMaterials Science Centre, University of Manchester, Oxford Road, Manchester, M13 9PT, UKDepartment of Trauma and Orthopaedics, Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, SK2 7JE, UKRoyal National Orthopaedic Hospital and Institute of Orthopaedics and Musculoskeletal Science, University College London, Stanmore, Middlesex, HA7 4LP, UKMaterials Science Centre, University of Manchester, Oxford Road, Manchester, M13 9PT, UKDepartment of Trauma and Orthopaedics, Stepping Hill Hospital, Stockport NHS Foundation Trust, Stockport, SK2 7JE, UKTissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. We evaluate the current literature on ligament tissue engineering and its role in anterior cruciate ligament reconstruction.http://dx.doi.org/10.1155/2012/438125 |
| spellingShingle | E. W. Yates A. Rupani G. T. Foley W. S. Khan S. Cartmell S. J. Anand Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction Stem Cells International |
| title | Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction |
| title_full | Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction |
| title_fullStr | Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction |
| title_full_unstemmed | Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction |
| title_short | Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction |
| title_sort | ligament tissue engineering and its potential role in anterior cruciate ligament reconstruction |
| url | http://dx.doi.org/10.1155/2012/438125 |
| work_keys_str_mv | AT ewyates ligamenttissueengineeringanditspotentialroleinanteriorcruciateligamentreconstruction AT arupani ligamenttissueengineeringanditspotentialroleinanteriorcruciateligamentreconstruction AT gtfoley ligamenttissueengineeringanditspotentialroleinanteriorcruciateligamentreconstruction AT wskhan ligamenttissueengineeringanditspotentialroleinanteriorcruciateligamentreconstruction AT scartmell ligamenttissueengineeringanditspotentialroleinanteriorcruciateligamentreconstruction AT sjanand ligamenttissueengineeringanditspotentialroleinanteriorcruciateligamentreconstruction |