The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target

The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target

IntroductionOsteosarcoma (OS) is a malignant bone tumor with high metastatic potential and poor long-term survival. The tumor immune microenvironment and metabolic reprogramming are increasingly recognized as key drivers of OS progression, yet the molecular links between these systems remain unclear...

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Main Authors:	Yunpeng Zou, Jianning Kang, Shaopeng Zhu, Xuechen Ren, Zheng Li, Jiayao Niu, Xuanzhe Qin, Hongbo Li, Lu Xiang, Wei Jiang, Jiangbo Zhong, Ying Zhang, Kai Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	osteosarcoma immune microenvironment molecular biomarkers multi-omics analysis single-cell RNA sequencing PLEK
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1651858/full
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