Novel design of drug delivery in stented arteries:A numerical comparative study
Implantation of drug eluting stents following percutaneoustransluminal angioplasty has revealed a well establishedtechnique for treating occlusions caused bythe atherosclerotic plaque.However, due to the risk of vascular re-occlusion,other alternative therapeutic strategiesof drug delivery are curre...
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| Format: | Article |
| Language: | English |
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AIMS Press
2009-05-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.493 |
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| author | Mario Grassi Giuseppe Pontrelli Luciano Teresi Gabriele Grassi Lorenzo Comel Alessio Ferluga Luigi Galasso |
| author_facet | Mario Grassi Giuseppe Pontrelli Luciano Teresi Gabriele Grassi Lorenzo Comel Alessio Ferluga Luigi Galasso |
| author_sort | Mario Grassi |
| collection | DOAJ |
| description | Implantation of drug eluting stents following percutaneoustransluminal angioplasty has revealed a well establishedtechnique for treating occlusions caused bythe atherosclerotic plaque.However, due to the risk of vascular re-occlusion,other alternative therapeutic strategiesof drug delivery are currently being investigated.Polymeric endoluminal pave stenting is an emerging technologyfor preventing blood erosion and for optimizing drug release.The classical and novel methodologies are compared througha mathematical model able to predict the evolution ofthe drug concentration in a cross-section of the wall.Though limited to an idealized configuration, the presentmodel is shown to catch most of the relevant aspects ofthe drug dynamics in a delivery system.Results of numerical simulations shows that a bi-layer gel paved stenting guarantees a uniform drug elution anda prolonged perfusionof the tissues, and remains a promising and effective techniquein drug delivery. |
| format | Article |
| id | doaj-art-f4b541667eee4212bb52e43ab958297d |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2009-05-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-f4b541667eee4212bb52e43ab958297d2025-01-24T01:59:54ZengAIMS PressMathematical Biosciences and Engineering1551-00182009-05-016349350810.3934/mbe.2009.6.493Novel design of drug delivery in stented arteries:A numerical comparative studyMario Grassi0Giuseppe Pontrelli1Luciano Teresi2Gabriele Grassi3Lorenzo Comel4Alessio Ferluga5Luigi Galasso6Dept. of Chemical Engineering, University of TriesteDept. of Chemical Engineering, University of TriesteDept. of Chemical Engineering, University of TriesteDept. of Chemical Engineering, University of TriesteDept. of Chemical Engineering, University of TriesteDept. of Chemical Engineering, University of TriesteDept. of Chemical Engineering, University of TriesteImplantation of drug eluting stents following percutaneoustransluminal angioplasty has revealed a well establishedtechnique for treating occlusions caused bythe atherosclerotic plaque.However, due to the risk of vascular re-occlusion,other alternative therapeutic strategiesof drug delivery are currently being investigated.Polymeric endoluminal pave stenting is an emerging technologyfor preventing blood erosion and for optimizing drug release.The classical and novel methodologies are compared througha mathematical model able to predict the evolution ofthe drug concentration in a cross-section of the wall.Though limited to an idealized configuration, the presentmodel is shown to catch most of the relevant aspects ofthe drug dynamics in a delivery system.Results of numerical simulations shows that a bi-layer gel paved stenting guarantees a uniform drug elution anda prolonged perfusionof the tissues, and remains a promising and effective techniquein drug delivery.https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.493mathematical modellingfinite elements.numerical methodsarterial stentingdrug delivery |
| spellingShingle | Mario Grassi Giuseppe Pontrelli Luciano Teresi Gabriele Grassi Lorenzo Comel Alessio Ferluga Luigi Galasso Novel design of drug delivery in stented arteries:A numerical comparative study Mathematical Biosciences and Engineering mathematical modelling finite elements. numerical methods arterial stenting drug delivery |
| title | Novel design of drug delivery in stented arteries:A numerical comparative study |
| title_full | Novel design of drug delivery in stented arteries:A numerical comparative study |
| title_fullStr | Novel design of drug delivery in stented arteries:A numerical comparative study |
| title_full_unstemmed | Novel design of drug delivery in stented arteries:A numerical comparative study |
| title_short | Novel design of drug delivery in stented arteries:A numerical comparative study |
| title_sort | novel design of drug delivery in stented arteries a numerical comparative study |
| topic | mathematical modelling finite elements. numerical methods arterial stenting drug delivery |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.493 |
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