Chimeric Antigen Receptor (CAR)-NK92 cells effective against glioblastoma, breast- and pancreatic cancer in vitro and in a murine xenograft model of ovarian cancer

Chimeric Antigen Receptor (CAR)-NK92 cells effective against glioblastoma, breast- and pancreatic cancer in vitro and in a murine xenograft model of ovarian cancer

Abstract Background Aggressive tumors such as glioblastoma, breast, ovarian and pancreatic cancer have low survival rates and new therapies are urgently needed. One potential target is CD44v6, a splice variant of CD44 that is associated with poor prognosis. Recently, NK cells expressing CAR molecule...

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Bibliographic Details
Main Authors: Abdelhadi Boulifa, Alexander Sebastian Franzén, Martin J. Raftery, Clarissa Radecke, Gabriele Pecher
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
Glioblastoma
Breast cancer
Pancreatic cancer
Ovarian cancer
CD44v6
CAR-NK
Online Access:https://doi.org/10.1186/s12935-025-03865-0
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