C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis
Elevated serum levels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain. However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/121679 |
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| author | Liara Rizzi Fabricio Correia Marques Idiane Rosset Emilio Hideyuki Moriguchi Paulo Dornelles Picon Marcia Lorena Fagundes Chaves Matheus Roriz-Cruz |
| author_facet | Liara Rizzi Fabricio Correia Marques Idiane Rosset Emilio Hideyuki Moriguchi Paulo Dornelles Picon Marcia Lorena Fagundes Chaves Matheus Roriz-Cruz |
| author_sort | Liara Rizzi |
| collection | DOAJ |
| description | Elevated serum levels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain. However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (P: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%, P: 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (P: 0.012). We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis. |
| format | Article |
| id | doaj-art-f4a48f2b1a124ed586ae66982678d9c2 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-f4a48f2b1a124ed586ae66982678d9c22025-02-03T06:06:58ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/121679121679C-Reactive Protein and Cognition Are Unrelated to LeukoaraiosisLiara Rizzi0Fabricio Correia Marques1Idiane Rosset2Emilio Hideyuki Moriguchi3Paulo Dornelles Picon4Marcia Lorena Fagundes Chaves5Matheus Roriz-Cruz6Division of Geriatric Neurology, Service of Neurology, “Hospital de Clinicas de Porto Alegre” (HCPA), Ramiro Barcelos Street 2.350, 90035-903 Porto Alegre, RS, BrazilDivision of Geriatric Neurology, Service of Neurology, “Hospital de Clinicas de Porto Alegre” (HCPA), Ramiro Barcelos Street 2.350, 90035-903 Porto Alegre, RS, BrazilDivision of Gerontological Nursing, Faculty of Nursing, Federal University of Rio Grande do Sul (UFRGS), São Manoel Street 963, 90620-110 Porto Alegre, RS, BrazilDepartment of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street 2.040, 90035-903 Porto Alegre, RS, BrazilDepartment of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street 2.040, 90035-903 Porto Alegre, RS, BrazilDivision of Geriatric Neurology, Service of Neurology, “Hospital de Clinicas de Porto Alegre” (HCPA), Ramiro Barcelos Street 2.350, 90035-903 Porto Alegre, RS, BrazilDivision of Geriatric Neurology, Service of Neurology, “Hospital de Clinicas de Porto Alegre” (HCPA), Ramiro Barcelos Street 2.350, 90035-903 Porto Alegre, RS, BrazilElevated serum levels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain. However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (P: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%, P: 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (P: 0.012). We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis.http://dx.doi.org/10.1155/2014/121679 |
| spellingShingle | Liara Rizzi Fabricio Correia Marques Idiane Rosset Emilio Hideyuki Moriguchi Paulo Dornelles Picon Marcia Lorena Fagundes Chaves Matheus Roriz-Cruz C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis The Scientific World Journal |
| title | C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis |
| title_full | C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis |
| title_fullStr | C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis |
| title_full_unstemmed | C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis |
| title_short | C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis |
| title_sort | c reactive protein and cognition are unrelated to leukoaraiosis |
| url | http://dx.doi.org/10.1155/2014/121679 |
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