Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT
<b>Background/Objectives</b>: Diffuse myocardial fibrosis and altered deformation are relevant prognostic factors in aortic stenosis (AS) patients. The aim of this exploratory study was to investigate the relationship between myocardial strain, and myocardial extracellular volume (ECV) i...
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2025-01-01
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| author | Costanza Lisi Victor Mergen Lukas J. Moser Konstantin Klambauer Jonathan Michel Albert M. Kasel Hatem Alkadhi Matthias Eberhard |
| author_facet | Costanza Lisi Victor Mergen Lukas J. Moser Konstantin Klambauer Jonathan Michel Albert M. Kasel Hatem Alkadhi Matthias Eberhard |
| author_sort | Costanza Lisi |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Diffuse myocardial fibrosis and altered deformation are relevant prognostic factors in aortic stenosis (AS) patients. The aim of this exploratory study was to investigate the relationship between myocardial strain, and myocardial extracellular volume (ECV) in patients with severe AS with a photon-counting detector (PCD)-CT. <b>Methods</b>: We retrospectively included 77 patients with severe AS undergoing PCD-CT imaging for transcatheter aortic valve replacement (TAVR) planning between January 2022 and May 2024 with a protocol including a non-contrast cardiac scan, an ECG-gated helical coronary CT angiography (CCTA), and a cardiac late enhancement scan. Myocardial strain was assessed with feature tracking from CCTA and ECV was calculated from spectral cardiac late enhancement scans. <b>Results</b>: Patients with cardiac amyloidosis (<i>n</i> = 4) exhibited significantly higher median mid-myocardial ECV (48.2% versus 25.5%, <i>p</i> = 0.048) but no significant differences in strain values (<i>p</i> > 0.05). Patients with prior myocardial infarction (<i>n</i> = 6) had reduced median global longitudinal strain values (−9.1% versus −21.7%, <i>p</i> < 0.001) but no significant differences in global mid-myocardial ECV (<i>p</i> > 0.05). Significant correlations were identified between the global longitudinal, circumferential, and radial strains and the CT-derived left ventricular ejection fraction (EF) (all, <i>p</i> < 0.001). Patients with low-flow, low-gradient AS and reduced EF exhibited lower median global longitudinal strain values compared with those with high-gradient AS (−15.2% versus −25.8%, <i>p</i> < 0.001). In these patients, the baso-apical mid-myocardial ECV gradient correlated with GLS values (R = 0.28, <i>p</i> = 0.02). <b>Conclusions</b>: In patients undergoing PCD-CT for TAVR planning, ECV and GLS may enable us to detect patients with cardiac amyloidosis and reduced myocardial contractility |
| format | Article |
| id | doaj-art-f48ff40cd7164e089990be167a98ae11 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Diagnostics |
| spelling | doaj-art-f48ff40cd7164e089990be167a98ae112025-01-24T13:29:10ZengMDPI AGDiagnostics2075-44182025-01-0115222410.3390/diagnostics15020224Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CTCostanza Lisi0Victor Mergen1Lukas J. Moser2Konstantin Klambauer3Jonathan Michel4Albert M. Kasel5Hatem Alkadhi6Matthias Eberhard7Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, SwitzerlandDiagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, SwitzerlandDiagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, SwitzerlandDiagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, CH-8091 Zurich, SwitzerlandDepartment of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, CH-8091 Zurich, SwitzerlandDiagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, SwitzerlandDiagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland<b>Background/Objectives</b>: Diffuse myocardial fibrosis and altered deformation are relevant prognostic factors in aortic stenosis (AS) patients. The aim of this exploratory study was to investigate the relationship between myocardial strain, and myocardial extracellular volume (ECV) in patients with severe AS with a photon-counting detector (PCD)-CT. <b>Methods</b>: We retrospectively included 77 patients with severe AS undergoing PCD-CT imaging for transcatheter aortic valve replacement (TAVR) planning between January 2022 and May 2024 with a protocol including a non-contrast cardiac scan, an ECG-gated helical coronary CT angiography (CCTA), and a cardiac late enhancement scan. Myocardial strain was assessed with feature tracking from CCTA and ECV was calculated from spectral cardiac late enhancement scans. <b>Results</b>: Patients with cardiac amyloidosis (<i>n</i> = 4) exhibited significantly higher median mid-myocardial ECV (48.2% versus 25.5%, <i>p</i> = 0.048) but no significant differences in strain values (<i>p</i> > 0.05). Patients with prior myocardial infarction (<i>n</i> = 6) had reduced median global longitudinal strain values (−9.1% versus −21.7%, <i>p</i> < 0.001) but no significant differences in global mid-myocardial ECV (<i>p</i> > 0.05). Significant correlations were identified between the global longitudinal, circumferential, and radial strains and the CT-derived left ventricular ejection fraction (EF) (all, <i>p</i> < 0.001). Patients with low-flow, low-gradient AS and reduced EF exhibited lower median global longitudinal strain values compared with those with high-gradient AS (−15.2% versus −25.8%, <i>p</i> < 0.001). In these patients, the baso-apical mid-myocardial ECV gradient correlated with GLS values (R = 0.28, <i>p</i> = 0.02). <b>Conclusions</b>: In patients undergoing PCD-CT for TAVR planning, ECV and GLS may enable us to detect patients with cardiac amyloidosis and reduced myocardial contractilityhttps://www.mdpi.com/2075-4418/15/2/224photon-counting detector CTmyocardial strainmyocardial extracellular volumeaortic stenosistranscatheter aortic valve replacement |
| spellingShingle | Costanza Lisi Victor Mergen Lukas J. Moser Konstantin Klambauer Jonathan Michel Albert M. Kasel Hatem Alkadhi Matthias Eberhard Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT Diagnostics photon-counting detector CT myocardial strain myocardial extracellular volume aortic stenosis transcatheter aortic valve replacement |
| title | Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT |
| title_full | Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT |
| title_fullStr | Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT |
| title_full_unstemmed | Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT |
| title_short | Relationship Between Myocardial Strain and Extracellular Volume: Exploratory Study in Patients with Severe Aortic Stenosis Undergoing Photon-Counting Detector CT |
| title_sort | relationship between myocardial strain and extracellular volume exploratory study in patients with severe aortic stenosis undergoing photon counting detector ct |
| topic | photon-counting detector CT myocardial strain myocardial extracellular volume aortic stenosis transcatheter aortic valve replacement |
| url | https://www.mdpi.com/2075-4418/15/2/224 |
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