Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata
A 21-year-old Bangladesh-born man presented with a month history of evolving neurological symptoms in the context of a six-month history of fever, night sweats, and axillary lymphadenopathy. He was subsequently diagnosed with multiple multidrug resistant intracranial tuberculomata and was successful...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/1841529 |
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| _version_ | 1832555822850244608 |
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| author | Richard P. Sullivan Hazel F. Goldberg Ross S. Mellick Jeffrey J. Post |
| author_facet | Richard P. Sullivan Hazel F. Goldberg Ross S. Mellick Jeffrey J. Post |
| author_sort | Richard P. Sullivan |
| collection | DOAJ |
| description | A 21-year-old Bangladesh-born man presented with a month history of evolving neurological symptoms in the context of a six-month history of fever, night sweats, and axillary lymphadenopathy. He was subsequently diagnosed with multiple multidrug resistant intracranial tuberculomata and was successfully treated over two years. Intracranial multidrug resistant tuberculosis has a high mortality and successful treatment is rarely reported. Management is complex and requires consideration of the penetration and likely effect of antituberculous agents within the central nervous system. We discuss the role of various antituberculous agents, the duration of therapy, the utility of corticosteroids, the value of intrathecal and systemic therapy, and the need for rapid diagnosis. |
| format | Article |
| id | doaj-art-f48aeb0a46e54fd7b331b657b14a6ec2 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-f48aeb0a46e54fd7b331b657b14a6ec22025-02-03T05:47:12ZengWileyCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/18415291841529Successful Treatment of Multiple Multidrug Resistant Intracranial TuberculomataRichard P. Sullivan0Hazel F. Goldberg1Ross S. Mellick2Jeffrey J. Post3Department of Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, AustraliaDepartment of Respiratory Medicine, Prince of Wales Hospital, Sydney, NSW, AustraliaInstitute of Neurological Sciences, Prince of Wales Hospital, Sydney, NSW, AustraliaDepartment of Infectious Diseases, Prince of Wales Hospital, Sydney, NSW, AustraliaA 21-year-old Bangladesh-born man presented with a month history of evolving neurological symptoms in the context of a six-month history of fever, night sweats, and axillary lymphadenopathy. He was subsequently diagnosed with multiple multidrug resistant intracranial tuberculomata and was successfully treated over two years. Intracranial multidrug resistant tuberculosis has a high mortality and successful treatment is rarely reported. Management is complex and requires consideration of the penetration and likely effect of antituberculous agents within the central nervous system. We discuss the role of various antituberculous agents, the duration of therapy, the utility of corticosteroids, the value of intrathecal and systemic therapy, and the need for rapid diagnosis.http://dx.doi.org/10.1155/2016/1841529 |
| spellingShingle | Richard P. Sullivan Hazel F. Goldberg Ross S. Mellick Jeffrey J. Post Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata Case Reports in Infectious Diseases |
| title | Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata |
| title_full | Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata |
| title_fullStr | Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata |
| title_full_unstemmed | Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata |
| title_short | Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata |
| title_sort | successful treatment of multiple multidrug resistant intracranial tuberculomata |
| url | http://dx.doi.org/10.1155/2016/1841529 |
| work_keys_str_mv | AT richardpsullivan successfultreatmentofmultiplemultidrugresistantintracranialtuberculomata AT hazelfgoldberg successfultreatmentofmultiplemultidrugresistantintracranialtuberculomata AT rosssmellick successfultreatmentofmultiplemultidrugresistantintracranialtuberculomata AT jeffreyjpost successfultreatmentofmultiplemultidrugresistantintracranialtuberculomata |