The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B
Herein, we discuss a case of a 39-year-old male with hemophilia B, who developed end-stage liver disease secondary to nonalcoholic steatohepatitis, that underwent orthotopic liver transplantation (OLT) as a curative means for his liver disease and coagulation disorder. Existing case reports have dem...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2020/7873803 |
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| author | Jesse E. Harris Jonathan L. Balk Constance M. Mobley Kirk Heyne |
| author_facet | Jesse E. Harris Jonathan L. Balk Constance M. Mobley Kirk Heyne |
| author_sort | Jesse E. Harris |
| collection | DOAJ |
| description | Herein, we discuss a case of a 39-year-old male with hemophilia B, who developed end-stage liver disease secondary to nonalcoholic steatohepatitis, that underwent orthotopic liver transplantation (OLT) as a curative means for his liver disease and coagulation disorder. Existing case reports have demonstrated favorable outcomes in patients outside of the United States who received continuous infusions of recombinant factor IX replacement in the perioperative setting after liver transplant. Given limitations in the stability of the recombinant factor IX products in the United States, a dosing strategy was comprised of once daily bolus dosing to achieve satisfactory factor IX levels. Within 48 hours of initial surgery, the patient had sustained factor IX levels above 70% of normal and the patient required no further dosing of factor IX products to date. This strategy helped facilitate less frequent dosing as well as achieved targeted factor levels while synthetic function of the transplanted liver recovered. |
| format | Article |
| id | doaj-art-f48849e047804ce5ae627692a90dcf39 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-f48849e047804ce5ae627692a90dcf392025-02-03T01:05:18ZengWileyCase Reports in Transplantation2090-69432090-69512020-01-01202010.1155/2020/78738037873803The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia BJesse E. Harris0Jonathan L. Balk1Constance M. Mobley2Kirk Heyne3Department of Pharmacy, Houston Methodist Hospital, USADepartment of Pharmacy, Houston Methodist Hospital, USADepartment of Transplant Surgery, Houston Methodist Hospital, USADepartment of Oncology, Houston Methodist Hospital, USAHerein, we discuss a case of a 39-year-old male with hemophilia B, who developed end-stage liver disease secondary to nonalcoholic steatohepatitis, that underwent orthotopic liver transplantation (OLT) as a curative means for his liver disease and coagulation disorder. Existing case reports have demonstrated favorable outcomes in patients outside of the United States who received continuous infusions of recombinant factor IX replacement in the perioperative setting after liver transplant. Given limitations in the stability of the recombinant factor IX products in the United States, a dosing strategy was comprised of once daily bolus dosing to achieve satisfactory factor IX levels. Within 48 hours of initial surgery, the patient had sustained factor IX levels above 70% of normal and the patient required no further dosing of factor IX products to date. This strategy helped facilitate less frequent dosing as well as achieved targeted factor levels while synthetic function of the transplanted liver recovered.http://dx.doi.org/10.1155/2020/7873803 |
| spellingShingle | Jesse E. Harris Jonathan L. Balk Constance M. Mobley Kirk Heyne The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B Case Reports in Transplantation |
| title | The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B |
| title_full | The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B |
| title_fullStr | The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B |
| title_full_unstemmed | The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B |
| title_short | The Liver That Cured Christmas: Case Report of Orthotopic Liver Transplant in a Patient with Hemophilia B |
| title_sort | liver that cured christmas case report of orthotopic liver transplant in a patient with hemophilia b |
| url | http://dx.doi.org/10.1155/2020/7873803 |
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