Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG
Despite the widespread use of transcranial magnetic stimulation (TMS), knowledge of its neurophysiological mode of action is still incomplete. Recently, TMS has been proposed to synchronise neural oscillators and to thereby increase the detectability of corresponding oscillations at the population l...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/6263907 |
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| author | Sarah Glim Yuka O. Okazaki Yumi Nakagawa Yuji Mizuno Takashi Hanakawa Keiichi Kitajo |
| author_facet | Sarah Glim Yuka O. Okazaki Yumi Nakagawa Yuji Mizuno Takashi Hanakawa Keiichi Kitajo |
| author_sort | Sarah Glim |
| collection | DOAJ |
| description | Despite the widespread use of transcranial magnetic stimulation (TMS), knowledge of its neurophysiological mode of action is still incomplete. Recently, TMS has been proposed to synchronise neural oscillators and to thereby increase the detectability of corresponding oscillations at the population level. As oscillations in the human brain are known to interact within nested hierarchies via phase-amplitude coupling, TMS might also be able to increase the macroscopic detectability of such coupling. In a concurrent TMS-electroencephalography study, we therefore examined the technique’s influence on theta-gamma, alpha-gamma, and beta-gamma phase-amplitude coupling by delivering single-pulse TMS (sTMS) and repetitive TMS (rTMS) over the left motor cortex and right visual cortex of healthy participants. The rTMS pulse trains were of 5 Hz, 11 Hz, and 23 Hz for the three coupling variations, respectively. Relative to sham stimulation, all conditions showed transient but significant increases in phase-amplitude coupling at the stimulation site. In addition, we observed enhanced coupling over various other cortical sites, with a more extensive propagation during rTMS than during sTMS. By indicating that scalp-recorded phase-amplitude coupling can be effectively probed with TMS, these findings open the door to the technique’s application in manipulative dissections of such coupling during human cognition and behaviour in healthy and pathological conditions. |
| format | Article |
| id | doaj-art-f46c02d579a844a49620c0598eeeba3f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-f46c02d579a844a49620c0598eeeba3f2025-02-03T01:10:26ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/62639076263907Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEGSarah Glim0Yuka O. Okazaki1Yumi Nakagawa2Yuji Mizuno3Takashi Hanakawa4Keiichi Kitajo5RIKEN CBS-TOYOTA Collaboration Center, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanRIKEN CBS-TOYOTA Collaboration Center, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanRIKEN CBS-TOYOTA Collaboration Center, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanRIKEN CBS-TOYOTA Collaboration Center, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanRIKEN CBS-TOYOTA Collaboration Center, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanRIKEN CBS-TOYOTA Collaboration Center, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanDespite the widespread use of transcranial magnetic stimulation (TMS), knowledge of its neurophysiological mode of action is still incomplete. Recently, TMS has been proposed to synchronise neural oscillators and to thereby increase the detectability of corresponding oscillations at the population level. As oscillations in the human brain are known to interact within nested hierarchies via phase-amplitude coupling, TMS might also be able to increase the macroscopic detectability of such coupling. In a concurrent TMS-electroencephalography study, we therefore examined the technique’s influence on theta-gamma, alpha-gamma, and beta-gamma phase-amplitude coupling by delivering single-pulse TMS (sTMS) and repetitive TMS (rTMS) over the left motor cortex and right visual cortex of healthy participants. The rTMS pulse trains were of 5 Hz, 11 Hz, and 23 Hz for the three coupling variations, respectively. Relative to sham stimulation, all conditions showed transient but significant increases in phase-amplitude coupling at the stimulation site. In addition, we observed enhanced coupling over various other cortical sites, with a more extensive propagation during rTMS than during sTMS. By indicating that scalp-recorded phase-amplitude coupling can be effectively probed with TMS, these findings open the door to the technique’s application in manipulative dissections of such coupling during human cognition and behaviour in healthy and pathological conditions.http://dx.doi.org/10.1155/2019/6263907 |
| spellingShingle | Sarah Glim Yuka O. Okazaki Yumi Nakagawa Yuji Mizuno Takashi Hanakawa Keiichi Kitajo Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG Neural Plasticity |
| title | Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG |
| title_full | Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG |
| title_fullStr | Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG |
| title_full_unstemmed | Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG |
| title_short | Phase-Amplitude Coupling of Neural Oscillations Can Be Effectively Probed with Concurrent TMS-EEG |
| title_sort | phase amplitude coupling of neural oscillations can be effectively probed with concurrent tms eeg |
| url | http://dx.doi.org/10.1155/2019/6263907 |
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