Diagnosis and Management of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension is a rare disease, which requires a high index of suspicion to diagnose when patients initially present. Initial symptoms can be nonspecific and include complaints such as fatigue and mild dyspnea. Once the disease is suspected, echocardiography is used to estimate th...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/845864 |
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| author | Jeanne Houtchens Douglas Martin James R. Klinger |
| author_facet | Jeanne Houtchens Douglas Martin James R. Klinger |
| author_sort | Jeanne Houtchens |
| collection | DOAJ |
| description | Pulmonary arterial hypertension is a rare disease, which requires a high index of suspicion to diagnose when patients initially present. Initial symptoms can be nonspecific and include complaints such as fatigue and mild dyspnea. Once the disease is suspected, echocardiography is used to estimate the pulmonary arterial (PA) pressure and to exclude secondary causes of elevated PA pressures such as left heart disease. Right heart catheterization with vasodilator challenge is critical to the proper assessment of pulmonary hemodynamics and to determine whether patients are likely to benefit from vasodilator therapy. Pathologically, the disease is characterized by deleterious remodeling of the distal pulmonary arterial and arteriolar circulation, which results in increased pulmonary vascular resistance. In the last fifteen years, medications from three different classes have been approved for the treatment of pulmonary arterial hypertension. These include the prostanoids, endothelin receptor antagonists, and phosphodiesterase-5 inhibitors. |
| format | Article |
| id | doaj-art-f464b01a97d74757a72f05167591aaf4 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-f464b01a97d74757a72f05167591aaf42025-02-03T01:31:08ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/845864845864Diagnosis and Management of Pulmonary Arterial HypertensionJeanne Houtchens0Douglas Martin1James R. Klinger2Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USADivision of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USADivision of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USAPulmonary arterial hypertension is a rare disease, which requires a high index of suspicion to diagnose when patients initially present. Initial symptoms can be nonspecific and include complaints such as fatigue and mild dyspnea. Once the disease is suspected, echocardiography is used to estimate the pulmonary arterial (PA) pressure and to exclude secondary causes of elevated PA pressures such as left heart disease. Right heart catheterization with vasodilator challenge is critical to the proper assessment of pulmonary hemodynamics and to determine whether patients are likely to benefit from vasodilator therapy. Pathologically, the disease is characterized by deleterious remodeling of the distal pulmonary arterial and arteriolar circulation, which results in increased pulmonary vascular resistance. In the last fifteen years, medications from three different classes have been approved for the treatment of pulmonary arterial hypertension. These include the prostanoids, endothelin receptor antagonists, and phosphodiesterase-5 inhibitors.http://dx.doi.org/10.1155/2011/845864 |
| spellingShingle | Jeanne Houtchens Douglas Martin James R. Klinger Diagnosis and Management of Pulmonary Arterial Hypertension Pulmonary Medicine |
| title | Diagnosis and Management of Pulmonary Arterial Hypertension |
| title_full | Diagnosis and Management of Pulmonary Arterial Hypertension |
| title_fullStr | Diagnosis and Management of Pulmonary Arterial Hypertension |
| title_full_unstemmed | Diagnosis and Management of Pulmonary Arterial Hypertension |
| title_short | Diagnosis and Management of Pulmonary Arterial Hypertension |
| title_sort | diagnosis and management of pulmonary arterial hypertension |
| url | http://dx.doi.org/10.1155/2011/845864 |
| work_keys_str_mv | AT jeannehoutchens diagnosisandmanagementofpulmonaryarterialhypertension AT douglasmartin diagnosisandmanagementofpulmonaryarterialhypertension AT jamesrklinger diagnosisandmanagementofpulmonaryarterialhypertension |