Sensing of Liver‐Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility

Sensing of Liver‐Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility

Abstract The correlation between liver disease and the progression of ulcerative colitis (UC) has remained elusive. In this study, it demonstrates that liver injury is intricately linked to the heightened severity of UC in patients, and causes more profound intestinal damage during DSS‐induced colit...

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Main Authors: Jing Shen, Zhen Li, Xiaoyu Liu, Mengqi Zheng, Peng Zhang, Yatai Chen, Qiuheng Tian, Wenyu Tian, Guanjun Kou, Yanyan Cui, Bowen Xu, Yunjiao Zhai, Weijia Li, Xiaohuan Guo, Ju Qiu, Chunyang Li, Ran He, Lixiang Li, Chunhong Ma, Yanqing Li, Xiuli Zuo, Detian Yuan, Shiyang Li
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
group 2 innate lymphoid cells
liver injury
liver‐gut axis
NAD+ metabolism
nicotinamide phosphoribosyltransferase
ulcerative colitis
Online Access:https://doi.org/10.1002/advs.202404274
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