BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways

BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways

Summary: Progression following androgen-deprivation therapy (ADT) and the development of castration resistance is the leading cause of death among prostate cancer patients. Since there is currently a lack of known driver alterations associated with ADT resistance in castration-sensitive prostate can...

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Main Authors: Rahim Hirani, Subhiksha Nandakumar, Nabila Zaman, Prathiksha Prabhakaraalva, Sarah Ann King, Teja Muralidhar Kalidindi, Romina Ghale, Sai Harisha Rajanala, Deborah C. Fidele, Elisa De Stanchina, Gwo-Shu Mary Lee, Mary Ellen Taplin, Steven P. Balk, Adam G. Sowalsky, Michael J. Morris, Naga Vara Kishore Pillarsetty, Konrad H. Stopsack, Anuradha Gopalan, Lorelei A. Mucci, Natasha Kyprianou, Ashutosh K. Tewari, Daniel Danila, Philip W. Kantoff, Goutam Chakraborty
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005509
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