Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children
Variations in different urinary measurements for evaluating iodine status are concerning to clinicians and researchers. The present study aimed to analyze the interindividual and intraindividual variations in the urinary iodine concentration (UIC) and urinary iodine/creatinine (UI/Cr) ratio and eval...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/6779094 |
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| author | Dong An Rui Yang Yuping Du Xuan Wang Ying Yang Wenxing Guo Junhong Yang Dongmei Meng Weiwei Gao Jiayi Zhang Wen Chen Wanqi Zhang |
| author_facet | Dong An Rui Yang Yuping Du Xuan Wang Ying Yang Wenxing Guo Junhong Yang Dongmei Meng Weiwei Gao Jiayi Zhang Wen Chen Wanqi Zhang |
| author_sort | Dong An |
| collection | DOAJ |
| description | Variations in different urinary measurements for evaluating iodine status are concerning to clinicians and researchers. The present study aimed to analyze the interindividual and intraindividual variations in the urinary iodine concentration (UIC) and urinary iodine/creatinine (UI/Cr) ratio and evaluate their application in assessing the iodine nutrition of preschool children. Four repeated spot urine samples were collected from 163 children at different times within one day. The urinary iodine concentration (UIC) and urinary creatinine concentration (UCr) were measured, and the UI/Cr ratio was calculated. The UIC (P < 0.001) and urinary iodine/creatinine ratio (P = 0.019) of multiple measurements were significantly different. The UIC of morning urine was highest (99.83 μg/L) and then gradually decreased with collection time (P < 0.001). In contrast, the UI/Cr ratio of morning urine samples increased with collection time. By computing the mean intraindividual and interindividual coefficients of variance (CV), the intraindividual variation of the UI/Cr ratio (68%) was significantly lower than that of the UIC (86%). Nevertheless, the interindividual variation was lowest in the UIC (78.62%) of morning urine. In addition, the UIC and UI/Cr ratio showed moderate correlations (r = 0.52, P < 0.001), with kappa values of 0.42 in assessing iodine nutrition. The UIC of morning urine samples taken at 8:00–10:00 am was perhaps more stable and reliable in evaluating the iodine nutrition of preschool children at the population level. The UI/Cr ratio showed lower intraindividual variation and may be more suitable for assessing individual iodine nutrition. |
| format | Article |
| id | doaj-art-f447574cc2eb4bd7935be17bdb175210 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f447574cc2eb4bd7935be17bdb1752102025-02-03T06:47:46ZengWileyInternational Journal of Endocrinology1687-83452023-01-01202310.1155/2023/6779094Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool ChildrenDong An0Rui Yang1Yuping Du2Xuan Wang3Ying Yang4Wenxing Guo5Junhong Yang6Dongmei Meng7Weiwei Gao8Jiayi Zhang9Wen Chen10Wanqi Zhang11Department of Nutrition and Food HygieneDepartment of Nutrition and Food HygieneDepartment of Clinical NutritionDepartment of Nutrition and Food HygieneDepartment of Nutrition and Food HygieneDepartment of Nutrition and Food HygieneTianjin Children’s Hospital (Tianjin University Children’s Hospital)Tianjin Children’s Hospital (Tianjin University Children’s Hospital)Tianjin Children’s Hospital (Tianjin University Children’s Hospital)Tianjin Children’s Hospital (Tianjin University Children’s Hospital)Department of Nutrition and Food HygieneDepartment of Nutrition and Food HygieneVariations in different urinary measurements for evaluating iodine status are concerning to clinicians and researchers. The present study aimed to analyze the interindividual and intraindividual variations in the urinary iodine concentration (UIC) and urinary iodine/creatinine (UI/Cr) ratio and evaluate their application in assessing the iodine nutrition of preschool children. Four repeated spot urine samples were collected from 163 children at different times within one day. The urinary iodine concentration (UIC) and urinary creatinine concentration (UCr) were measured, and the UI/Cr ratio was calculated. The UIC (P < 0.001) and urinary iodine/creatinine ratio (P = 0.019) of multiple measurements were significantly different. The UIC of morning urine was highest (99.83 μg/L) and then gradually decreased with collection time (P < 0.001). In contrast, the UI/Cr ratio of morning urine samples increased with collection time. By computing the mean intraindividual and interindividual coefficients of variance (CV), the intraindividual variation of the UI/Cr ratio (68%) was significantly lower than that of the UIC (86%). Nevertheless, the interindividual variation was lowest in the UIC (78.62%) of morning urine. In addition, the UIC and UI/Cr ratio showed moderate correlations (r = 0.52, P < 0.001), with kappa values of 0.42 in assessing iodine nutrition. The UIC of morning urine samples taken at 8:00–10:00 am was perhaps more stable and reliable in evaluating the iodine nutrition of preschool children at the population level. The UI/Cr ratio showed lower intraindividual variation and may be more suitable for assessing individual iodine nutrition.http://dx.doi.org/10.1155/2023/6779094 |
| spellingShingle | Dong An Rui Yang Yuping Du Xuan Wang Ying Yang Wenxing Guo Junhong Yang Dongmei Meng Weiwei Gao Jiayi Zhang Wen Chen Wanqi Zhang Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children International Journal of Endocrinology |
| title | Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children |
| title_full | Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children |
| title_fullStr | Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children |
| title_full_unstemmed | Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children |
| title_short | Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children |
| title_sort | variations in the urinary iodine concentration and urinary iodine creatinine ratio among preschool children |
| url | http://dx.doi.org/10.1155/2023/6779094 |
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