Muscle Satellite Cells: Exploring the Basic Biology to Rule Them
Adult skeletal muscle is a postmitotic tissue with an enormous capacity to regenerate upon injury. This is accomplished by resident stem cells, named satellite cells, which were identified more than 50 years ago. Since their discovery, many researchers have been concentrating efforts to answer quest...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1078686 |
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| _version_ | 1832561189318557696 |
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| author | Camila F. Almeida Stephanie A. Fernandes Antonio F. Ribeiro Junior Oswaldo Keith Okamoto Mariz Vainzof |
| author_facet | Camila F. Almeida Stephanie A. Fernandes Antonio F. Ribeiro Junior Oswaldo Keith Okamoto Mariz Vainzof |
| author_sort | Camila F. Almeida |
| collection | DOAJ |
| description | Adult skeletal muscle is a postmitotic tissue with an enormous capacity to regenerate upon injury. This is accomplished by resident stem cells, named satellite cells, which were identified more than 50 years ago. Since their discovery, many researchers have been concentrating efforts to answer questions about their origin and role in muscle development, the way they contribute to muscle regeneration, and their potential to cell-based therapies. Satellite cells are maintained in a quiescent state and upon requirement are activated, proliferating, and fusing with other cells to form or repair myofibers. In addition, they are able to self-renew and replenish the stem pool. Every phase of satellite cell activity is highly regulated and orchestrated by many molecules and signaling pathways; the elucidation of players and mechanisms involved in satellite cell biology is of extreme importance, being the first step to expose the crucial points that could be modulated to extract the optimal response from these cells in therapeutic strategies. Here, we review the basic aspects about satellite cells biology and briefly discuss recent findings about therapeutic attempts, trying to raise questions about how basic biology could provide a solid scaffold to more successful use of these cells in clinics. |
| format | Article |
| id | doaj-art-f43c0589045943158d046a0f0f065af8 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f43c0589045943158d046a0f0f065af82025-02-03T01:25:52ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/10786861078686Muscle Satellite Cells: Exploring the Basic Biology to Rule ThemCamila F. Almeida0Stephanie A. Fernandes1Antonio F. Ribeiro Junior2Oswaldo Keith Okamoto3Mariz Vainzof4Human Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, BrazilHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, BrazilHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, BrazilHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, BrazilHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, BrazilAdult skeletal muscle is a postmitotic tissue with an enormous capacity to regenerate upon injury. This is accomplished by resident stem cells, named satellite cells, which were identified more than 50 years ago. Since their discovery, many researchers have been concentrating efforts to answer questions about their origin and role in muscle development, the way they contribute to muscle regeneration, and their potential to cell-based therapies. Satellite cells are maintained in a quiescent state and upon requirement are activated, proliferating, and fusing with other cells to form or repair myofibers. In addition, they are able to self-renew and replenish the stem pool. Every phase of satellite cell activity is highly regulated and orchestrated by many molecules and signaling pathways; the elucidation of players and mechanisms involved in satellite cell biology is of extreme importance, being the first step to expose the crucial points that could be modulated to extract the optimal response from these cells in therapeutic strategies. Here, we review the basic aspects about satellite cells biology and briefly discuss recent findings about therapeutic attempts, trying to raise questions about how basic biology could provide a solid scaffold to more successful use of these cells in clinics.http://dx.doi.org/10.1155/2016/1078686 |
| spellingShingle | Camila F. Almeida Stephanie A. Fernandes Antonio F. Ribeiro Junior Oswaldo Keith Okamoto Mariz Vainzof Muscle Satellite Cells: Exploring the Basic Biology to Rule Them Stem Cells International |
| title | Muscle Satellite Cells: Exploring the Basic Biology to Rule Them |
| title_full | Muscle Satellite Cells: Exploring the Basic Biology to Rule Them |
| title_fullStr | Muscle Satellite Cells: Exploring the Basic Biology to Rule Them |
| title_full_unstemmed | Muscle Satellite Cells: Exploring the Basic Biology to Rule Them |
| title_short | Muscle Satellite Cells: Exploring the Basic Biology to Rule Them |
| title_sort | muscle satellite cells exploring the basic biology to rule them |
| url | http://dx.doi.org/10.1155/2016/1078686 |
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