Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome
We report a case of acute aortic dissection in a lady of 28 weeks of gestation with undiagnosed Marfan syndrome. The patient had been seen in our antenatal clinics. Her history documented in her pregnancy record was negative for genetic/congenital abnormalities. There was no family history documente...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2012/490169 |
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| author | Mandana Master Gavin Day |
| author_facet | Mandana Master Gavin Day |
| author_sort | Mandana Master |
| collection | DOAJ |
| description | We report a case of acute aortic dissection in a lady of 28 weeks of gestation with undiagnosed Marfan syndrome. The patient had been seen in our antenatal clinics. Her history documented in her pregnancy record was negative for genetic/congenital abnormalities. There was no family history documented. Subsequently, at 28 weeks of gestation, the patient presented with sudden onset chest, jaw, and back pain. Further history revealed that her father had died at the age of 27 of an aortic dissection. Echocardiography showed aortic root dissection with occlusion of aortic branches. She subsequently underwent an emergency lower segment caesarean section followed by surgical repair of type A dissection. A simultaneous type B dissection was managed conservatively. On later examination, our patient fulfilled the diagnostic criteria for phenotypic expression of Marfan syndrome. Genetic testing also confirmed that she has a mutation of the fibrillin (FBN 1) gene associated with the disease. |
| format | Article |
| id | doaj-art-f42c9ce68e294eb5b9f73fc922e06eec |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-f42c9ce68e294eb5b9f73fc922e06eec2025-02-03T01:10:59ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922012-01-01201210.1155/2012/490169490169Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan SyndromeMandana Master0Gavin Day1Department of Obstetrics and Gynaecology, Women’s and Children’s Hospital, Adelaide, SA 5006, AustraliaDepartment of Cardiothoracic Surgery, Flinders Medical Centre, Adelaide, SA 5142, AustraliaWe report a case of acute aortic dissection in a lady of 28 weeks of gestation with undiagnosed Marfan syndrome. The patient had been seen in our antenatal clinics. Her history documented in her pregnancy record was negative for genetic/congenital abnormalities. There was no family history documented. Subsequently, at 28 weeks of gestation, the patient presented with sudden onset chest, jaw, and back pain. Further history revealed that her father had died at the age of 27 of an aortic dissection. Echocardiography showed aortic root dissection with occlusion of aortic branches. She subsequently underwent an emergency lower segment caesarean section followed by surgical repair of type A dissection. A simultaneous type B dissection was managed conservatively. On later examination, our patient fulfilled the diagnostic criteria for phenotypic expression of Marfan syndrome. Genetic testing also confirmed that she has a mutation of the fibrillin (FBN 1) gene associated with the disease.http://dx.doi.org/10.1155/2012/490169 |
| spellingShingle | Mandana Master Gavin Day Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome Case Reports in Obstetrics and Gynecology |
| title | Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome |
| title_full | Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome |
| title_fullStr | Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome |
| title_full_unstemmed | Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome |
| title_short | Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome |
| title_sort | acute aortic dissection in pregnancy in a woman with undiagnosed marfan syndrome |
| url | http://dx.doi.org/10.1155/2012/490169 |
| work_keys_str_mv | AT mandanamaster acuteaorticdissectioninpregnancyinawomanwithundiagnosedmarfansyndrome AT gavinday acuteaorticdissectioninpregnancyinawomanwithundiagnosedmarfansyndrome |