Immunomodulatory Properties of HLA-G in Infectious Diseases
HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions. The expression of this molecule ha...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/298569 |
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| author | Laurence Amiot Nicolas Vu Michel Samson |
| author_facet | Laurence Amiot Nicolas Vu Michel Samson |
| author_sort | Laurence Amiot |
| collection | DOAJ |
| description | HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions. The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. The relevance of studies on HLA-G expression lies in the well known inhibitory effect of this molecule on all cell types involved in innate and adaptive immunity, favoring escape from immune control. In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent. The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections. We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G. New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases. |
| format | Article |
| id | doaj-art-f41e5513467f4467826b2dbdeda4a9f8 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f41e5513467f4467826b2dbdeda4a9f82025-02-03T01:12:07ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/298569298569Immunomodulatory Properties of HLA-G in Infectious DiseasesLaurence Amiot0Nicolas Vu1Michel Samson2Institut National de la Santé et de la Recherche Médicale (Inserm), U.1085, Institut de Recherche sur la Santé, l'Environnement, et le Travail (IRSET), 2 Avenue du Pr. Leon Bernard CS 34317, 35043 Rennes, FranceInstitut National de la Santé et de la Recherche Médicale (Inserm), U.1085, Institut de Recherche sur la Santé, l'Environnement, et le Travail (IRSET), 2 Avenue du Pr. Leon Bernard CS 34317, 35043 Rennes, FranceInstitut National de la Santé et de la Recherche Médicale (Inserm), U.1085, Institut de Recherche sur la Santé, l'Environnement, et le Travail (IRSET), 2 Avenue du Pr. Leon Bernard CS 34317, 35043 Rennes, FranceHLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions. The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. The relevance of studies on HLA-G expression lies in the well known inhibitory effect of this molecule on all cell types involved in innate and adaptive immunity, favoring escape from immune control. In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent. The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections. We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G. New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases.http://dx.doi.org/10.1155/2014/298569 |
| spellingShingle | Laurence Amiot Nicolas Vu Michel Samson Immunomodulatory Properties of HLA-G in Infectious Diseases Journal of Immunology Research |
| title | Immunomodulatory Properties of HLA-G in Infectious Diseases |
| title_full | Immunomodulatory Properties of HLA-G in Infectious Diseases |
| title_fullStr | Immunomodulatory Properties of HLA-G in Infectious Diseases |
| title_full_unstemmed | Immunomodulatory Properties of HLA-G in Infectious Diseases |
| title_short | Immunomodulatory Properties of HLA-G in Infectious Diseases |
| title_sort | immunomodulatory properties of hla g in infectious diseases |
| url | http://dx.doi.org/10.1155/2014/298569 |
| work_keys_str_mv | AT laurenceamiot immunomodulatorypropertiesofhlagininfectiousdiseases AT nicolasvu immunomodulatorypropertiesofhlagininfectiousdiseases AT michelsamson immunomodulatorypropertiesofhlagininfectiousdiseases |