Impaired Urine Dilution Capability in HIV Stable Patients
Renal disease is a well-recognized complication among patients with HIV infection. Viral infection itself and the use of some antiretroviral drugs contribute to this condition. The thick ascending limb of Henle’s loop (TALH) is the tubule segment where free water clearance is generated, determining...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/381985 |
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| author | Waldo H. Belloso Mariana de Paz Sierra Matilde Navarro Marisa L. Sanchez Ariel G. Perelsztein Carlos G. Musso |
| author_facet | Waldo H. Belloso Mariana de Paz Sierra Matilde Navarro Marisa L. Sanchez Ariel G. Perelsztein Carlos G. Musso |
| author_sort | Waldo H. Belloso |
| collection | DOAJ |
| description | Renal disease is a well-recognized complication among patients with HIV infection. Viral infection itself and the use of some antiretroviral drugs contribute to this condition. The thick ascending limb of Henle’s loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney’s ability to dilute urine. Objective. We analyzed the function of the proximal tubule and TALH in patients with HIV infection receiving or not tenofovir-containing antiretroviral treatment in comparison with healthy seronegative controls, by applying a tubular physiological test, hyposaline infusion test (Chaimowitz’ test). Material & Methods. Chaimowitz’ test was performed on 20 HIV positive volunteers who had normal renal functional parameters. The control group included 10 healthy volunteers. Results. After the test, both HIV groups had a significant reduction of serum sodium and osmolarity compared with the control group. Free water clearance was lower and urine osmolarity was higher in both HIV+ groups. Proximal tubular function was normal in both studied groups. Conclusion. The present study documented that proximal tubule sodium reabsorption was preserved while free water clearance and maximal urine dilution capability were reduced in stable HIV patients treated or not with tenofovir. |
| format | Article |
| id | doaj-art-f4163d9526b443bb8947de0839884605 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-f4163d9526b443bb8947de08398846052025-02-03T07:23:52ZengWileyInternational Journal of Nephrology2090-214X2090-21582014-01-01201410.1155/2014/381985381985Impaired Urine Dilution Capability in HIV Stable PatientsWaldo H. Belloso0Mariana de Paz Sierra1Matilde Navarro2Marisa L. Sanchez3Ariel G. Perelsztein4Carlos G. Musso5Infectious Diseases Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, ArgentinaInfectious Diseases Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, ArgentinaRenal Physiology Section, Nephrology Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, ArgentinaInfectious Diseases Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, ArgentinaInfectious Diseases Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, ArgentinaRenal Physiology Section, Nephrology Service, Hospital Italiano de Buenos Aires, Peron 4190, 1181 ACH Buenos Aires, ArgentinaRenal disease is a well-recognized complication among patients with HIV infection. Viral infection itself and the use of some antiretroviral drugs contribute to this condition. The thick ascending limb of Henle’s loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney’s ability to dilute urine. Objective. We analyzed the function of the proximal tubule and TALH in patients with HIV infection receiving or not tenofovir-containing antiretroviral treatment in comparison with healthy seronegative controls, by applying a tubular physiological test, hyposaline infusion test (Chaimowitz’ test). Material & Methods. Chaimowitz’ test was performed on 20 HIV positive volunteers who had normal renal functional parameters. The control group included 10 healthy volunteers. Results. After the test, both HIV groups had a significant reduction of serum sodium and osmolarity compared with the control group. Free water clearance was lower and urine osmolarity was higher in both HIV+ groups. Proximal tubular function was normal in both studied groups. Conclusion. The present study documented that proximal tubule sodium reabsorption was preserved while free water clearance and maximal urine dilution capability were reduced in stable HIV patients treated or not with tenofovir.http://dx.doi.org/10.1155/2014/381985 |
| spellingShingle | Waldo H. Belloso Mariana de Paz Sierra Matilde Navarro Marisa L. Sanchez Ariel G. Perelsztein Carlos G. Musso Impaired Urine Dilution Capability in HIV Stable Patients International Journal of Nephrology |
| title | Impaired Urine Dilution Capability in HIV Stable Patients |
| title_full | Impaired Urine Dilution Capability in HIV Stable Patients |
| title_fullStr | Impaired Urine Dilution Capability in HIV Stable Patients |
| title_full_unstemmed | Impaired Urine Dilution Capability in HIV Stable Patients |
| title_short | Impaired Urine Dilution Capability in HIV Stable Patients |
| title_sort | impaired urine dilution capability in hiv stable patients |
| url | http://dx.doi.org/10.1155/2014/381985 |
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