Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD

Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD

Sclerostin (Sost) functions as an inhibitor of the Wnt/β-catenin signaling pathway, which is known to promote kidney cell epithelial-to-mesenchymal transition (EMT), and fibrosis in chronic kidney disease (CKD). However, the renoprotective effects of Sost in kidney diseases and its therapeutic poten...

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Bibliographic Details
Main Authors: Rang-yue Han, Rui-zhi Tan, Ling-hui Xu, Jing-yi Lin, Tong Li, Hong-wei Su, Ping Li, Peng Liu, Hui-yao Lan, Li Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
CKD
Fibrosis
Isg20
Sost
Hederagenin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002757
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