Bone-Immune Cell Crosstalk: Bone Diseases
Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mech...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/108451 |
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| _version_ | 1832545614007631872 |
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| author | Giorgio Mori Patrizia D’Amelio Roberta Faccio Giacomina Brunetti |
| author_facet | Giorgio Mori Patrizia D’Amelio Roberta Faccio Giacomina Brunetti |
| author_sort | Giorgio Mori |
| collection | DOAJ |
| description | Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma. |
| format | Article |
| id | doaj-art-f4126be14dc64341aac524df1124f7a9 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f4126be14dc64341aac524df1124f7a92025-02-03T07:25:25ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/108451108451Bone-Immune Cell Crosstalk: Bone DiseasesGiorgio Mori0Patrizia D’Amelio1Roberta Faccio2Giacomina Brunetti3Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Medical Science, Section of Gerontology and Bone Metabolism Diseases, University of Torino, 10126 Torino, ItalyDepartment of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USADepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, ItalyBone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma.http://dx.doi.org/10.1155/2015/108451 |
| spellingShingle | Giorgio Mori Patrizia D’Amelio Roberta Faccio Giacomina Brunetti Bone-Immune Cell Crosstalk: Bone Diseases Journal of Immunology Research |
| title | Bone-Immune Cell Crosstalk: Bone Diseases |
| title_full | Bone-Immune Cell Crosstalk: Bone Diseases |
| title_fullStr | Bone-Immune Cell Crosstalk: Bone Diseases |
| title_full_unstemmed | Bone-Immune Cell Crosstalk: Bone Diseases |
| title_short | Bone-Immune Cell Crosstalk: Bone Diseases |
| title_sort | bone immune cell crosstalk bone diseases |
| url | http://dx.doi.org/10.1155/2015/108451 |
| work_keys_str_mv | AT giorgiomori boneimmunecellcrosstalkbonediseases AT patriziadamelio boneimmunecellcrosstalkbonediseases AT robertafaccio boneimmunecellcrosstalkbonediseases AT giacominabrunetti boneimmunecellcrosstalkbonediseases |