Apoptosis-inducing factor (AIF) at the crossroad of cell survival and cell death: implications for cancer and mitochondrial diseases

Apoptosis-inducing factor (AIF) at the crossroad of cell survival and cell death: implications for cancer and mitochondrial diseases

Abstract Apoptosis-inducing factor (AIF), a mitochondrial NAD(P)H-dependent oxidoreductase, was initially studied as a cell death inducer in a process later named parthanatos. However, it has been revealed that AIF also participates in mitochondrial bioenergetics through interaction with its partner...

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Bibliographic Details
Main Authors: Tran Ngoc Anh Nguyen, Hong-Toan Lai, Romain Fernandes, Filippo G Dall’Olio, Camille Blériot, Tap Ha-Duong, Catherine Brenner
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
Apoptosis-inducing factor (AIF)
Cell death
Mitochondrial protein import
Mitochondrial diseases
Cancer
Online Access:https://doi.org/10.1186/s12964-025-02272-2
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https://doi.org/10.1186/s12964-025-02272-2

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