Glyoxylate, a New Marker Metabolite of Type 2 Diabetes
Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AG...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/685204 |
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| author | Victoria J. Nikiforova Pieter Giesbertz Jan Wiemer Bianca Bethan Ralf Looser Volker Liebenberg Patricia Ruiz Noppinger Hannelore Daniel Dietrich Rein |
| author_facet | Victoria J. Nikiforova Pieter Giesbertz Jan Wiemer Bianca Bethan Ralf Looser Volker Liebenberg Patricia Ruiz Noppinger Hannelore Daniel Dietrich Rein |
| author_sort | Victoria J. Nikiforova |
| collection | DOAJ |
| description | Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-Leprdb/db-/- mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control P=0.034). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies. |
| format | Article |
| id | doaj-art-f3e8d94c546244db8ee323cd62a957d4 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-f3e8d94c546244db8ee323cd62a957d42025-02-03T07:24:49ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/685204685204Glyoxylate, a New Marker Metabolite of Type 2 DiabetesVictoria J. Nikiforova0Pieter Giesbertz1Jan Wiemer2Bianca Bethan3Ralf Looser4Volker Liebenberg5Patricia Ruiz Noppinger6Hannelore Daniel7Dietrich Rein8Metanomics Health GmbH, 10589 Berlin, GermanyZIEL Research Center for Nutrition and Food Sciences, Biochemistry Unit, Technische Universität München, 85354 Freising, Germanymetanomics GmbH, 10589 Berlin, Germanymetanomics GmbH, 10589 Berlin, Germanymetanomics GmbH, 10589 Berlin, GermanyMetanomics Health GmbH, 10589 Berlin, GermanyMetanomics Health GmbH, 10589 Berlin, GermanyZIEL Research Center for Nutrition and Food Sciences, Biochemistry Unit, Technische Universität München, 85354 Freising, GermanyMetanomics Health GmbH, 10589 Berlin, GermanyType 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-Leprdb/db-/- mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control P=0.034). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.http://dx.doi.org/10.1155/2014/685204 |
| spellingShingle | Victoria J. Nikiforova Pieter Giesbertz Jan Wiemer Bianca Bethan Ralf Looser Volker Liebenberg Patricia Ruiz Noppinger Hannelore Daniel Dietrich Rein Glyoxylate, a New Marker Metabolite of Type 2 Diabetes Journal of Diabetes Research |
| title | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_full | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_fullStr | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_full_unstemmed | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_short | Glyoxylate, a New Marker Metabolite of Type 2 Diabetes |
| title_sort | glyoxylate a new marker metabolite of type 2 diabetes |
| url | http://dx.doi.org/10.1155/2014/685204 |
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