The structural basis for RNA slicing by human Argonaute2

Summary: Argonaute (AGO) proteins associate with guide RNAs to form complexes that slice transcripts that pair to the guide. This slicing drives post-transcriptional gene silencing through RNA interference (RNAi), which is essential for many eukaryotes and the basis for new clinical therapies. Despi...

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Bibliographic Details
Main Authors: Abdallah A. Mohamed, Peter Y. Wang, David P. Bartel, Seychelle M. Vos
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724015171
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