Neutrophil-derived Oxidants and Proteinases as Immunomodulatory Mediators in Inflammation
Neutrophils generate potent microbicidal molecules via the oxygen-dependent pathway, leading to the generation of reactive oxygen intermediates (ROI), and via the non-oxygen dependent pathway, consisting in the release of serine proteinases and metalloproteinases stored in granules. Over the past ye...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000360 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Neutrophils generate potent microbicidal molecules via the
oxygen-dependent pathway, leading to the generation of reactive
oxygen intermediates (ROI), and via the non-oxygen dependent pathway,
consisting in the release of serine proteinases and
metalloproteinases stored in granules. Over the past years, the
concept has emerged that both ROI and proteinases can be viewed as
mediators able to modulate neutrophil responses as well as the whole
inflammatory process. This is well illustrated by the oxidative
regulation of proteinase activity showing that oxidants and
proteinases acts is concert to optimize the microbicidal activity
and to damage host tissues. ROI and proteinases can modify the
activity of several proteins involved in the control of inflammatory
process. Among them, tumour necrosis factor-α and
interleukin-8, are elective targets for such a modulation. Moreover,
ROI and proteinases are also able to modulate the adhesion process
of neutrophils to endothelial cells, which is a critical step in the
inflammatory process. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |