Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells
Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenicall...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/5747298 |
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| _version_ | 1832567003066400768 |
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| author | Aofei Yang Chaochao Yu Qilin Lu Hao Li Zhanghua Li Chengjian He |
| author_facet | Aofei Yang Chaochao Yu Qilin Lu Hao Li Zhanghua Li Chengjian He |
| author_sort | Aofei Yang |
| collection | DOAJ |
| description | Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is the active ingredient of Herba epimedii, a common herb used in traditional Chinese medicine (TCM) formulations, and can effectively enhance BMSC proliferation and osteogenesis. However, the underlying mechanism of ICA action in BMSCs is not completely clear. In this review, we provide an overview of the studies on the role and mechanism of action of ICA in BMSCs, to provide greater insights into its potential clinical use in bone regeneration. |
| format | Article |
| id | doaj-art-f3cdd90e40e940c3852731a53c3a3dfc |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f3cdd90e40e940c3852731a53c3a3dfc2025-02-03T01:02:42ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/57472985747298Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem CellsAofei Yang0Chaochao Yu1Qilin Lu2Hao Li3Zhanghua Li4Chengjian He5Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061 Hubei, ChinaHubei University of Chinese Medicine, Wuhan, 430061 Hubei, ChinaHubei 672 Orthopaedics Hospital of Integrated Chinese & Western Medicine, Wuhan, 430079 Hubei, ChinaHubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061 Hubei, ChinaTongren Hospital of Wuhan University, Wuhan, 430060 Hubei, ChinaHubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061 Hubei, ChinaOsteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is the active ingredient of Herba epimedii, a common herb used in traditional Chinese medicine (TCM) formulations, and can effectively enhance BMSC proliferation and osteogenesis. However, the underlying mechanism of ICA action in BMSCs is not completely clear. In this review, we provide an overview of the studies on the role and mechanism of action of ICA in BMSCs, to provide greater insights into its potential clinical use in bone regeneration.http://dx.doi.org/10.1155/2019/5747298 |
| spellingShingle | Aofei Yang Chaochao Yu Qilin Lu Hao Li Zhanghua Li Chengjian He Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells Stem Cells International |
| title | Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells |
| title_full | Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells |
| title_fullStr | Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells |
| title_full_unstemmed | Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells |
| title_short | Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells |
| title_sort | mechanism of action of icariin in bone marrow mesenchymal stem cells |
| url | http://dx.doi.org/10.1155/2019/5747298 |
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