Impact of Incretin-Based Therapies on Adipokines and Adiponectin
Adipokines are a family of hormones and cytokines with both pro- and anti-inflammatory effects released into the circulation to exert their hormonal effects. Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/3331865 |
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| author | Habib Yaribeygi Mina Maleki Stephen L. Atkin Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_facet | Habib Yaribeygi Mina Maleki Stephen L. Atkin Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_sort | Habib Yaribeygi |
| collection | DOAJ |
| description | Adipokines are a family of hormones and cytokines with both pro- and anti-inflammatory effects released into the circulation to exert their hormonal effects. Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they are involved in the pathophysiology of most metabolic disorders. Incretin-based therapy is a newly introduced class of antidiabetic drugs that restores euglycemia through several cellular processes; however, its effect on adipokines expression/secretion is not fully understood. In this review, we propose that incretin-based therapy may function through adipokine modulation that may result in pharmacologic properties beyond their direct antidiabetic effects, resulting in better management of diabetes and diabetes-related complications. |
| format | Article |
| id | doaj-art-f3c6d2a552e642289f6c6de814d752d5 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-f3c6d2a552e642289f6c6de814d752d52025-02-03T01:25:09ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/33318653331865Impact of Incretin-Based Therapies on Adipokines and AdiponectinHabib Yaribeygi0Mina Maleki1Stephen L. Atkin2Tannaz Jamialahmadi3Amirhossein Sahebkar4Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranWeill Cornell Medicine Qatar, Doha, QatarDepartment of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranAdipokines are a family of hormones and cytokines with both pro- and anti-inflammatory effects released into the circulation to exert their hormonal effects. Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they are involved in the pathophysiology of most metabolic disorders. Incretin-based therapy is a newly introduced class of antidiabetic drugs that restores euglycemia through several cellular processes; however, its effect on adipokines expression/secretion is not fully understood. In this review, we propose that incretin-based therapy may function through adipokine modulation that may result in pharmacologic properties beyond their direct antidiabetic effects, resulting in better management of diabetes and diabetes-related complications.http://dx.doi.org/10.1155/2021/3331865 |
| spellingShingle | Habib Yaribeygi Mina Maleki Stephen L. Atkin Tannaz Jamialahmadi Amirhossein Sahebkar Impact of Incretin-Based Therapies on Adipokines and Adiponectin Journal of Diabetes Research |
| title | Impact of Incretin-Based Therapies on Adipokines and Adiponectin |
| title_full | Impact of Incretin-Based Therapies on Adipokines and Adiponectin |
| title_fullStr | Impact of Incretin-Based Therapies on Adipokines and Adiponectin |
| title_full_unstemmed | Impact of Incretin-Based Therapies on Adipokines and Adiponectin |
| title_short | Impact of Incretin-Based Therapies on Adipokines and Adiponectin |
| title_sort | impact of incretin based therapies on adipokines and adiponectin |
| url | http://dx.doi.org/10.1155/2021/3331865 |
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