Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods
Background/Aim. Vinegar is one of the main international traditional nutraceuticals, and it has been used as a vaginal health protectant due to vagina pH balance maintenance and antimicrobial properties. Since the main form of vinegar is liquid, it is difficult to apply vaginally due to its short re...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2022-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000121P.pdf |
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| author | Parvinroo Shirin Eslami Maede Ebrahimi-Najafabadi Heshmatollah Hesari Zahra |
| author_facet | Parvinroo Shirin Eslami Maede Ebrahimi-Najafabadi Heshmatollah Hesari Zahra |
| author_sort | Parvinroo Shirin |
| collection | DOAJ |
| description | Background/Aim. Vinegar is one of the main international traditional nutraceuticals, and it has been used as a vaginal health protectant due to vagina pH balance maintenance and antimicrobial properties. Since the main form of vinegar is liquid, it is difficult to apply vaginally due to its short retention. The aim of this study was to design a vaginal mucoadhesive gel made of vinegar. Methods. Xanthan gum and tragacanth were utilized as natural gel-forming polymers. The effects of xanthan gum and tragacanth on mucoadhesion strength and drug release of the gel formulations were optimized using a 3 level (32) factorial design. Several physico-chemical properties of the gel formulations, including gel viscosity, lubricity, scanning electron microscopy (SEM) images of hydrogel chains, and chain release kinetic, were also investigated. Results. It was found that tragacanth possessed a statistically significant effect on release rate control (p-value = 0.0027), while both tragacanth and xanthan gum had a significant effect (p-value = 0.0001 and 0.0017, respectively) on mucoadhesion property. Formulation F7 with 5% xanthan gum and 1% tragacanth (mucoadhesion = 0.4632 N and re-lease rate = 88.8% in 6 hours) considered as the optimum formulation with some modifications. Conclusion. Xanthan gum and tragacanth can be considered as appropriate natural polymers for vaginal drug delivery. |
| format | Article |
| id | doaj-art-f3b9e48e69fd43ce933a831a53b5b36e |
| institution | DOAJ |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-f3b9e48e69fd43ce933a831a53b5b36e2025-08-20T03:20:00ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202022-01-0179433734410.2298/VSP200804121P0042-84502000121PNatural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methodsParvinroo Shirin0Eslami Maede1Ebrahimi-Najafabadi Heshmatollah2Hesari Zahra3Guilan University of Medical Sciences, Faculty of Pharmacy, Department of Pharmacognosy, Rasht, IranGuilan University of Medical Sciences, Faculty of Pharmacy, Department of Pharmaceutics, Rasht, IranGuilan University of Medical Sciences, Faculty of Pharmacy, Department of Medicinal Chemistry, Rasht, IranGuilan University of Medical Sciences, Faculty of Pharmacy, Department of Pharmacognosy, Rasht, Iran + Guilan University of Medical Sciences, Faculty of Pharmacy, Department of Pharmaceutics, Rasht, IranBackground/Aim. Vinegar is one of the main international traditional nutraceuticals, and it has been used as a vaginal health protectant due to vagina pH balance maintenance and antimicrobial properties. Since the main form of vinegar is liquid, it is difficult to apply vaginally due to its short retention. The aim of this study was to design a vaginal mucoadhesive gel made of vinegar. Methods. Xanthan gum and tragacanth were utilized as natural gel-forming polymers. The effects of xanthan gum and tragacanth on mucoadhesion strength and drug release of the gel formulations were optimized using a 3 level (32) factorial design. Several physico-chemical properties of the gel formulations, including gel viscosity, lubricity, scanning electron microscopy (SEM) images of hydrogel chains, and chain release kinetic, were also investigated. Results. It was found that tragacanth possessed a statistically significant effect on release rate control (p-value = 0.0027), while both tragacanth and xanthan gum had a significant effect (p-value = 0.0001 and 0.0017, respectively) on mucoadhesion property. Formulation F7 with 5% xanthan gum and 1% tragacanth (mucoadhesion = 0.4632 N and re-lease rate = 88.8% in 6 hours) considered as the optimum formulation with some modifications. Conclusion. Xanthan gum and tragacanth can be considered as appropriate natural polymers for vaginal drug delivery.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000121P.pdfacetic acidgelspolymerstragacanthvaginal creams, foams, jelliesxanthan gum |
| spellingShingle | Parvinroo Shirin Eslami Maede Ebrahimi-Najafabadi Heshmatollah Hesari Zahra Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods Vojnosanitetski Pregled acetic acid gels polymers tragacanth vaginal creams, foams, jellies xanthan gum |
| title | Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods |
| title_full | Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods |
| title_fullStr | Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods |
| title_full_unstemmed | Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods |
| title_short | Natural polymers for vaginal mucoadhesive delivery of vinegar, using design of experiment methods |
| title_sort | natural polymers for vaginal mucoadhesive delivery of vinegar using design of experiment methods |
| topic | acetic acid gels polymers tragacanth vaginal creams, foams, jellies xanthan gum |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502000121P.pdf |
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