Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis
Background and objective: Lyme disease, caused by Borrelia burgdorferi, presents major health challenges worldwide, leading to serious neurological and musculoskeletal issues that impact patients' lives and healthcare systems. This systematic review and meta-analysis aim to determine the preval...
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Elsevier
2025-02-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354624002096 |
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| author | Ganesh Bushi Ashok Kumar Balaraman Shilpa Gaidhane Suhas Ballal Sanjay Kumar Mahakshit Bhat Shilpa Sharma M Ravi Kumar Aashna Sinha Mahalaqua Nazli Khatib Nishant Rai Sanjit Sah Ambanna Yappalparvi Shailesh Kumar Samal Doddolla Lingamaiah Muhammed Shabil |
| author_facet | Ganesh Bushi Ashok Kumar Balaraman Shilpa Gaidhane Suhas Ballal Sanjay Kumar Mahakshit Bhat Shilpa Sharma M Ravi Kumar Aashna Sinha Mahalaqua Nazli Khatib Nishant Rai Sanjit Sah Ambanna Yappalparvi Shailesh Kumar Samal Doddolla Lingamaiah Muhammed Shabil |
| author_sort | Ganesh Bushi |
| collection | DOAJ |
| description | Background and objective: Lyme disease, caused by Borrelia burgdorferi, presents major health challenges worldwide, leading to serious neurological and musculoskeletal issues that impact patients' lives and healthcare systems. This systematic review and meta-analysis aim to determine the prevalence and link between Lyme disease and these complications, aiming to enhance clinical and public health approaches. Methods: We systematically searched PubMed, EMBASE, and Web of Science up until April 01, 2024, to find studies reporting the prevalence and severity of neurological and musculoskeletal complications associated with Lyme disease. Screening and data extraction were conducted using Nested Knowledge software. Two independent reviewers performed the quality assessment using the Newcastle-Ottawa Scale. Meta-analyses were performed using R software v4.3, employing a random-effects model. Results: Out of 3576 records, 17 studies were included, involving 3932 participants. These studies revealed significant prevalence of musculoskeletal symptoms (21.1%) and neurological disabilities (18%) among Lyme disease patients. The analysis showed a notable increase in risk for both complications in individuals with Lyme disease, with pooled Risk Ratios (RR) of 1.82 for musculoskeletal symptoms and 1.64 for neurological disabilities, indicating a significantly higher risk compared to control groups. Although heterogeneity across the studies was high, sensitivity analysis confirmed the consistency of our findings. Additionally, there was evidence of publication bias. Conclusion: The study reveals significant neurological and musculoskeletal complications in Lyme disease patients, emphasizing the importance of early diagnosis, comprehensive treatment, and supportive care. The noted heterogeneity and potential publication bias highlight the need for transparent research and further study on long-term outcomes. |
| format | Article |
| id | doaj-art-f3b96bcd99a54d09b6c696986c7ba7ce |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-f3b96bcd99a54d09b6c696986c7ba7ce2025-01-26T05:05:02ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-02-0143100931Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysisGanesh Bushi0Ashok Kumar Balaraman1Shilpa Gaidhane2Suhas Ballal3Sanjay Kumar4Mahakshit Bhat5Shilpa Sharma6M Ravi Kumar7Aashna Sinha8Mahalaqua Nazli Khatib9Nishant Rai10Sanjit Sah11Ambanna Yappalparvi12Shailesh Kumar Samal13Doddolla Lingamaiah14Muhammed Shabil15Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000, Cyberjaya, Selangor, Malaysia; Corresponding author. Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000, Cyberjaya, Selangor, MalaysiaOne Health Centre, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, IndiaDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, IndiaDepartment of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, IndiaDepartment of Medicine, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, IndiaChandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, 140307, Punjab, IndiaDepartment of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, IndiaUttaranchal Institute of Pharmaceutical Sciences, Division of Research and Innovation, Uttaranchal University, IndiaDivision of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India; Corresponding author.Department of Biotechnology, Graphic Era (Deemed to be University) , Clement Town, Dehradun, 248002, IndiaSR Sanjeevani Hospital, Kalyanpur, Siraha, 56517, Nepal; Department of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, 411018, Maharashtra, India; Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, 411018, Maharashtra, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, IndiaUnit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, 17177, Stockholm, Sweden; Corresponding author.Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, IndiaUniversity Center for Research and Development, Chandigarh University, Mohali, Punjab, India; Medical Laboratories Techniques Department, AL-Mustaqbal University, 51001, Hillah, Babil, IraqBackground and objective: Lyme disease, caused by Borrelia burgdorferi, presents major health challenges worldwide, leading to serious neurological and musculoskeletal issues that impact patients' lives and healthcare systems. This systematic review and meta-analysis aim to determine the prevalence and link between Lyme disease and these complications, aiming to enhance clinical and public health approaches. Methods: We systematically searched PubMed, EMBASE, and Web of Science up until April 01, 2024, to find studies reporting the prevalence and severity of neurological and musculoskeletal complications associated with Lyme disease. Screening and data extraction were conducted using Nested Knowledge software. Two independent reviewers performed the quality assessment using the Newcastle-Ottawa Scale. Meta-analyses were performed using R software v4.3, employing a random-effects model. Results: Out of 3576 records, 17 studies were included, involving 3932 participants. These studies revealed significant prevalence of musculoskeletal symptoms (21.1%) and neurological disabilities (18%) among Lyme disease patients. The analysis showed a notable increase in risk for both complications in individuals with Lyme disease, with pooled Risk Ratios (RR) of 1.82 for musculoskeletal symptoms and 1.64 for neurological disabilities, indicating a significantly higher risk compared to control groups. Although heterogeneity across the studies was high, sensitivity analysis confirmed the consistency of our findings. Additionally, there was evidence of publication bias. Conclusion: The study reveals significant neurological and musculoskeletal complications in Lyme disease patients, emphasizing the importance of early diagnosis, comprehensive treatment, and supportive care. The noted heterogeneity and potential publication bias highlight the need for transparent research and further study on long-term outcomes.http://www.sciencedirect.com/science/article/pii/S2666354624002096Lyme diseaseTick-borne diseasesMusculoskeletal symptomsNeurological disabilitiesSystematic reviewMeta-analysis |
| spellingShingle | Ganesh Bushi Ashok Kumar Balaraman Shilpa Gaidhane Suhas Ballal Sanjay Kumar Mahakshit Bhat Shilpa Sharma M Ravi Kumar Aashna Sinha Mahalaqua Nazli Khatib Nishant Rai Sanjit Sah Ambanna Yappalparvi Shailesh Kumar Samal Doddolla Lingamaiah Muhammed Shabil Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis Brain, Behavior, & Immunity - Health Lyme disease Tick-borne diseases Musculoskeletal symptoms Neurological disabilities Systematic review Meta-analysis |
| title | Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis |
| title_full | Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis |
| title_fullStr | Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis |
| title_full_unstemmed | Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis |
| title_short | Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis |
| title_sort | lyme disease associated neurological and musculoskeletal symptoms a systematic review and meta analysis |
| topic | Lyme disease Tick-borne diseases Musculoskeletal symptoms Neurological disabilities Systematic review Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2666354624002096 |
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