Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world study
Abstract Background Allergic rhinitis (AR) multimorbidity may need to be considered a specific disease because of distinct clinical and immunological differences from AR alone. Allergic multimorbidity often involves polysensitization, where allergen‐specific immunoglobulin E (IgE) plays a significan...
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Wiley
2025-01-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.70030 |
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| author | Ya‐Ting Li Qi‐Qing Ye Ya‐Xin Lu Ke‐Xin Yang Ping‐Ping Zhang Chang Chen Min Zhou Pei‐Ying Feng Zhuang‐Gui Chen |
| author_facet | Ya‐Ting Li Qi‐Qing Ye Ya‐Xin Lu Ke‐Xin Yang Ping‐Ping Zhang Chang Chen Min Zhou Pei‐Ying Feng Zhuang‐Gui Chen |
| author_sort | Ya‐Ting Li |
| collection | DOAJ |
| description | Abstract Background Allergic rhinitis (AR) multimorbidity may need to be considered a specific disease because of distinct clinical and immunological differences from AR alone. Allergic multimorbidity often involves polysensitization, where allergen‐specific immunoglobulin E (IgE) plays a significant role. Objective This study aims to explore differences in allergen IgE sensitization patterns between AR alone and AR multimorbidity. Methods A real‐world case‐control study was conducted with patients diagnosed with AR. Multivariate logistic regression analyzed the associations between AR multimorbidity and allergen sensitivity, allergen‐specific IgE levels, and the count of positive allergens. Results A cohort of 2275 patients with AR was included, of which 1100 (48.4%) presented with AR alone, while 1175 (51.6%) exhibited AR multimorbidity. Patients with AR multimorbidity had a more diverse allergen profile than those with AR alone. An increased number of positive ingested allergens had a higher odds ratio (OR) for AR multimorbidity compared with inhaled allergens (1.46 vs. 1.96) across all phenotypes. Sensitization to allergens and their allergen‐specific IgE levels, including dust mites, cat dander, and milk (p < 0.05), were associated with AR multimorbidity. In children, cat and dog dander were significant allergens associated with AR multimorbidity (p < 0.05). Conclusions Allergen sensitization patterns in AR multimorbidity differ from those in AR alone. Polysensitization, particularly to ingested allergens, increases the risk of allergic multimorbidity. The risk of allergic multimorbidity also increases with specific allergen positivity and higher allergen‐specific IgE levels. |
| format | Article |
| id | doaj-art-f3a9188f0e13436fa09e265722713622 |
| institution | Kabale University |
| issn | 2045-7022 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj-art-f3a9188f0e13436fa09e2657227136222025-01-29T05:38:33ZengWileyClinical and Translational Allergy2045-70222025-01-01151n/an/a10.1002/clt2.70030Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world studyYa‐Ting Li0Qi‐Qing Ye1Ya‐Xin Lu2Ke‐Xin Yang3Ping‐Ping Zhang4Chang Chen5Min Zhou6Pei‐Ying Feng7Zhuang‐Gui Chen8Department of Allergy Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaChildren's Medicine Centre Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaClinical Data Center The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaChildren's Medicine Centre Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDepartment of Allergy Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaZhongshan School of Medicine Sun Yat‐sen University Guangzhou ChinaDepartment of Allergy Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDepartment of Allergy Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDepartment of Allergy Third Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaAbstract Background Allergic rhinitis (AR) multimorbidity may need to be considered a specific disease because of distinct clinical and immunological differences from AR alone. Allergic multimorbidity often involves polysensitization, where allergen‐specific immunoglobulin E (IgE) plays a significant role. Objective This study aims to explore differences in allergen IgE sensitization patterns between AR alone and AR multimorbidity. Methods A real‐world case‐control study was conducted with patients diagnosed with AR. Multivariate logistic regression analyzed the associations between AR multimorbidity and allergen sensitivity, allergen‐specific IgE levels, and the count of positive allergens. Results A cohort of 2275 patients with AR was included, of which 1100 (48.4%) presented with AR alone, while 1175 (51.6%) exhibited AR multimorbidity. Patients with AR multimorbidity had a more diverse allergen profile than those with AR alone. An increased number of positive ingested allergens had a higher odds ratio (OR) for AR multimorbidity compared with inhaled allergens (1.46 vs. 1.96) across all phenotypes. Sensitization to allergens and their allergen‐specific IgE levels, including dust mites, cat dander, and milk (p < 0.05), were associated with AR multimorbidity. In children, cat and dog dander were significant allergens associated with AR multimorbidity (p < 0.05). Conclusions Allergen sensitization patterns in AR multimorbidity differ from those in AR alone. Polysensitization, particularly to ingested allergens, increases the risk of allergic multimorbidity. The risk of allergic multimorbidity also increases with specific allergen positivity and higher allergen‐specific IgE levels.https://doi.org/10.1002/clt2.70030allergen sensitization patternsallergic multimorbidityallergic rhinitispolysensitizationspecific immunoglobulin E |
| spellingShingle | Ya‐Ting Li Qi‐Qing Ye Ya‐Xin Lu Ke‐Xin Yang Ping‐Ping Zhang Chang Chen Min Zhou Pei‐Ying Feng Zhuang‐Gui Chen Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world study Clinical and Translational Allergy allergen sensitization patterns allergic multimorbidity allergic rhinitis polysensitization specific immunoglobulin E |
| title | Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world study |
| title_full | Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world study |
| title_fullStr | Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world study |
| title_full_unstemmed | Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world study |
| title_short | Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real‐world study |
| title_sort | allergen sensitization patterns allergic rhinitis with multimorbidity versus alone a real world study |
| topic | allergen sensitization patterns allergic multimorbidity allergic rhinitis polysensitization specific immunoglobulin E |
| url | https://doi.org/10.1002/clt2.70030 |
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