Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats
The present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, w...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/432493 |
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| author | Ana Carolina Luchini Déborah Mara Costa de Oliveira Cláudia Helena Pellizzon Luiz Claudio Di Stasi José Carlos Gomes |
| author_facet | Ana Carolina Luchini Déborah Mara Costa de Oliveira Cláudia Helena Pellizzon Luiz Claudio Di Stasi José Carlos Gomes |
| author_sort | Ana Carolina Luchini |
| collection | DOAJ |
| description | The present study aimed to clarify the role of mast cells in colitis with
relapse induced in Wistar rats by trinitrobenzenosulphonic
acid. Colitis induction increased the histamine concentration
in the colon, which peaked on day 26. The number of mast cells,
probably immature, was ten times higher on day 8. Different from
animals infected with intestinal parasites, after colitis remission,
mast cells do not migrate to the spleen, showing that mast cell
proliferation presents different characteristics depending on the
inflammation stimuli. Treatment with sulfasalazine, doxantrazole,
quercetin, or nedocromil did not increase the histamine concentration
or the mast cell number in the colon on day 26, thereby showing
absence of degranulation of these cells. In conclusion, although mast
cell proliferation is associated with colitis, these cells and their
mediators appear to play no clear role in the colitis with
relapses. |
| format | Article |
| id | doaj-art-f3a8757a35874e7480281a047097961d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f3a8757a35874e7480281a047097961d2025-02-03T05:59:43ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/432493432493Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar RatsAna Carolina Luchini0Déborah Mara Costa de Oliveira1Cláudia Helena Pellizzon2Luiz Claudio Di Stasi3José Carlos Gomes4Department of Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), 18618-000 Botucatu, SP, BrazilDepartment of Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), 18618-000 Botucatu, SP, BrazilDepartment of Morphology, Institute of Biosciences, São Paulo State University (UNESP), 18618-000 Botucatu, SP, BrazilDepartment of Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), 18618-000 Botucatu, SP, BrazilDepartment of Pharmacology, Institute of Biosciences, São Paulo State University (UNESP), 18618-000 Botucatu, SP, BrazilThe present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, which peaked on day 26. The number of mast cells, probably immature, was ten times higher on day 8. Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli. Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells. In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses.http://dx.doi.org/10.1155/2009/432493 |
| spellingShingle | Ana Carolina Luchini Déborah Mara Costa de Oliveira Cláudia Helena Pellizzon Luiz Claudio Di Stasi José Carlos Gomes Relationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Rats Mediators of Inflammation |
| title | Relationship between Mast Cells and the Colitis with Relapse
Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
| title_full | Relationship between Mast Cells and the Colitis with Relapse
Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
| title_fullStr | Relationship between Mast Cells and the Colitis with Relapse
Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
| title_full_unstemmed | Relationship between Mast Cells and the Colitis with Relapse
Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
| title_short | Relationship between Mast Cells and the Colitis with Relapse
Induced by Trinitrobenzesulphonic Acid in Wistar Rats |
| title_sort | relationship between mast cells and the colitis with relapse induced by trinitrobenzesulphonic acid in wistar rats |
| url | http://dx.doi.org/10.1155/2009/432493 |
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