Downregulation of the HCN1 Channel Alleviates Anxiety‐ and Depression‐Like Behaviors in Mice With Cerebral Ischemia–Reperfusion Injury by Suppressing the NLRP3 Inflammasome

Downregulation of the HCN1 Channel Alleviates Anxiety‐ and Depression‐Like Behaviors in Mice With Cerebral Ischemia–Reperfusion Injury by Suppressing the NLRP3 Inflammasome

Background Post‐stroke depression (PSD) is a prevalent neuropsychiatric complication of stroke. However, the mechanisms underlying PSD are still unclear. Here, we aimed to investigate the role of HCN1 (hyperpolarization‐activated cyclic nucleotide‐gated cation channel 1) in the pathogenesis of PSD a...

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Bibliographic Details
Main Authors: Mei Zhou, Xiaoqin Tao, Kuan Lin, Changlong Leng, Youhua Yang, Yuran Gui, Yaojian Sun, Meiling Zhou, Binlian Sun, Yiyuan Xia, Xiji Shu, Wei Liu
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cerebral ischemia/reperfusion injury
depression
HCN channels
hippocampus
NLRP3 inflammasome
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.038263
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