Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control Trial
Background: Capsuloganglionic hemorrhage with intraventricular hemorrhage (IVH) is always associated with higher mortality and morbidity [12]. So, we did a randomized control trail in patients requiring External ventricular Drain (EVD) for hypertensive IVH with and without instilling Urokinase; to k...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
National Board of Examinations
2025-07-01
|
| Series: | National Board of Examinations Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://natboard.edu.in/ejournal/articledtl?x=dmJTbkpqV1I1R1hmcWQ4Z1pqS1ZCQT09 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849425644107071488 |
|---|---|
| author | Kaveeze K S Balaji |
| author_facet | Kaveeze K S Balaji |
| author_sort | Kaveeze K |
| collection | DOAJ |
| description | Background: Capsuloganglionic hemorrhage with intraventricular hemorrhage (IVH) is always associated with higher mortality and morbidity [12]. So, we did a randomized control trail in patients requiring External ventricular Drain (EVD) for hypertensive IVH with and without instilling Urokinase; to know it’s effectiveness [19]. Methods: A computerized randomized controlled trial was carried out on 30 patients who needed EVD for hypertensive capsuloganglionic hemorrhage with IVH. Patients were randomly assigned to one of two groups: test (EVD + urokinase) or control (EVD only). Graeb scores, Glasgow Outcome Scale (GOS), ICU stay, GCS, and complications were compared before and after treatment. Results: The EVD + urokinase group had better functional outcomes, a shorter ICU stay (5.8 vs. 7.8 days, p=0.044), and a much larger drop in Graeb scores (p<0.001). There was no increased risk of infection or rebleeding. Conclusion: In Hypertensive Capsuloganglionic Hemorrhage with IVH, intraventricular fibrinolysis with urokinase is a safe and effective to improve the outcome of the patient. |
| format | Article |
| id | doaj-art-f39fca06f0f147a5ae87eb8c7c237bc4 |
| institution | Kabale University |
| issn | 2583-7524 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | National Board of Examinations |
| record_format | Article |
| series | National Board of Examinations Journal of Medical Sciences |
| spelling | doaj-art-f39fca06f0f147a5ae87eb8c7c237bc42025-08-20T03:29:43ZengNational Board of ExaminationsNational Board of Examinations Journal of Medical Sciences2583-75242025-07-01Volume 3779280010.61770/NBEJMS.2025.v03.i07.004Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control TrialKaveeze K0S Balaji1https://orcid.org/0000-0001-9098-1372Consultant Neurosurgeon, Meenakshi Hospital, Tanjavur, Tamilnadu, IndiaAssistant Professor Neurosurgery, St John’s Hospital, Bangalore, IndiaBackground: Capsuloganglionic hemorrhage with intraventricular hemorrhage (IVH) is always associated with higher mortality and morbidity [12]. So, we did a randomized control trail in patients requiring External ventricular Drain (EVD) for hypertensive IVH with and without instilling Urokinase; to know it’s effectiveness [19]. Methods: A computerized randomized controlled trial was carried out on 30 patients who needed EVD for hypertensive capsuloganglionic hemorrhage with IVH. Patients were randomly assigned to one of two groups: test (EVD + urokinase) or control (EVD only). Graeb scores, Glasgow Outcome Scale (GOS), ICU stay, GCS, and complications were compared before and after treatment. Results: The EVD + urokinase group had better functional outcomes, a shorter ICU stay (5.8 vs. 7.8 days, p=0.044), and a much larger drop in Graeb scores (p<0.001). There was no increased risk of infection or rebleeding. Conclusion: In Hypertensive Capsuloganglionic Hemorrhage with IVH, intraventricular fibrinolysis with urokinase is a safe and effective to improve the outcome of the patient.https://natboard.edu.in/ejournal/articledtl?x=dmJTbkpqV1I1R1hmcWQ4Z1pqS1ZCQT09ivhgareb scoreurokinase fibrinolysiscapsuloganglionic ich with ivh |
| spellingShingle | Kaveeze K S Balaji Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control Trial National Board of Examinations Journal of Medical Sciences ivh gareb score urokinase fibrinolysis capsuloganglionic ich with ivh |
| title | Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control Trial |
| title_full | Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control Trial |
| title_fullStr | Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control Trial |
| title_full_unstemmed | Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control Trial |
| title_short | Urokinase in Hypertensive Capsuloganglionic Hemorrhage with Intraventricular Hemorrhage: A Randomized Control Trial |
| title_sort | urokinase in hypertensive capsuloganglionic hemorrhage with intraventricular hemorrhage a randomized control trial |
| topic | ivh gareb score urokinase fibrinolysis capsuloganglionic ich with ivh |
| url | https://natboard.edu.in/ejournal/articledtl?x=dmJTbkpqV1I1R1hmcWQ4Z1pqS1ZCQT09 |
| work_keys_str_mv | AT kaveezek urokinaseinhypertensivecapsuloganglionichemorrhagewithintraventricularhemorrhagearandomizedcontroltrial AT sbalaji urokinaseinhypertensivecapsuloganglionichemorrhagewithintraventricularhemorrhagearandomizedcontroltrial |