Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or action. Diabetic nephropathy, a microvascular complication of type 2 DM, causes damage to kidney function due to progressive hyperglycemia. This study analyzed the potential of durian s...
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| Format: | Article |
| Language: | Arabic |
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Yayasan Pendidikan Islam dan Multikultural
2024-12-01
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| Series: | International Journal of Islamic Education, Research and Multiculturalism |
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| Online Access: | https://journal.yaspim.org/index.php/IJIERM/article/view/430 |
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| author | Livia Virgoh Tan Suyono Linda Chiuman Lia Nurlaela Michaela Kosasih Clarissa lister |
| author_facet | Livia Virgoh Tan Suyono Linda Chiuman Lia Nurlaela Michaela Kosasih Clarissa lister |
| author_sort | Livia Virgoh |
| collection | DOAJ |
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Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or action. Diabetic nephropathy, a microvascular complication of type 2 DM, causes damage to kidney function due to progressive hyperglycemia. This study analyzed the potential of durian seed extract in reducing blood sugar levels (KGD) and improving kidney function and histopathological features in streptozotocin (STZ)-induced Wistar rats. Rats were divided into six groups: normal, positive control (STZ + metformin), negative control (STZ), and three treatment groups with durian seed extract doses of 150, 300, and 450 mg/kgBB. The extract was given for 14 days, followed by examination of kidney function and histopathology. The results showed that a dose of 450 mg/kgBB was most effective in reducing KGD, equivalent to metformin, which could improve kidney function and histopathology. Durian seed extract 450 mg/kgBB has the potential as an effective antidiabetic in reducing kidney damage.
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| format | Article |
| id | doaj-art-f399f83079524a2cbd50a1e54153949c |
| institution | Kabale University |
| issn | 2656-3630 2722-7049 |
| language | Arabic |
| publishDate | 2024-12-01 |
| publisher | Yayasan Pendidikan Islam dan Multikultural |
| record_format | Article |
| series | International Journal of Islamic Education, Research and Multiculturalism |
| spelling | doaj-art-f399f83079524a2cbd50a1e54153949c2025-01-31T03:44:20ZaraYayasan Pendidikan Islam dan MultikulturalInternational Journal of Islamic Education, Research and Multiculturalism2656-36302722-70492024-12-016310.47006/ijierm.v6i3.430Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar StreptozotocinLivia Virgoh0Tan Suyono1Linda Chiuman2Lia Nurlaela3Michaela Kosasih4Clarissa lister 5Universitas Prima IndonesiaUniversitas Prima IndonesiaUniversitas Prima IndonesiaUniversitas Prima IndonesiaUniversitas Prima IndonesiaUniversitas Prima Indonesia Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or action. Diabetic nephropathy, a microvascular complication of type 2 DM, causes damage to kidney function due to progressive hyperglycemia. This study analyzed the potential of durian seed extract in reducing blood sugar levels (KGD) and improving kidney function and histopathological features in streptozotocin (STZ)-induced Wistar rats. Rats were divided into six groups: normal, positive control (STZ + metformin), negative control (STZ), and three treatment groups with durian seed extract doses of 150, 300, and 450 mg/kgBB. The extract was given for 14 days, followed by examination of kidney function and histopathology. The results showed that a dose of 450 mg/kgBB was most effective in reducing KGD, equivalent to metformin, which could improve kidney function and histopathology. Durian seed extract 450 mg/kgBB has the potential as an effective antidiabetic in reducing kidney damage. https://journal.yaspim.org/index.php/IJIERM/article/view/430AntidiabetesDurian SeedsStreptozotocinKidney FunctionHistopathology |
| spellingShingle | Livia Virgoh Tan Suyono Linda Chiuman Lia Nurlaela Michaela Kosasih Clarissa lister Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin International Journal of Islamic Education, Research and Multiculturalism Antidiabetes Durian Seeds Streptozotocin Kidney Function Histopathology |
| title | Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin |
| title_full | Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin |
| title_fullStr | Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin |
| title_full_unstemmed | Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin |
| title_short | Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin |
| title_sort | effectiveness of durian fruit seed extract durio zibethinus on kidney function and histopathology of rats induced by wistar streptozotocin |
| topic | Antidiabetes Durian Seeds Streptozotocin Kidney Function Histopathology |
| url | https://journal.yaspim.org/index.php/IJIERM/article/view/430 |
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