Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study
Aim. The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus. Methods. This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/7047909 |
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| author | Jong Ho Kim Sang Soo Kim In Joo Kim Bo Hyun Kim Ja Young Park Chang Won Lee Ji Hye Suk Sun Hae Shin Sung Pyo Son Min Chul Kim Jun Hyeob Ahn Kwang Jae Lee Min Jung Kwon Soon Hee Lee Jeong Hyun Park |
| author_facet | Jong Ho Kim Sang Soo Kim In Joo Kim Bo Hyun Kim Ja Young Park Chang Won Lee Ji Hye Suk Sun Hae Shin Sung Pyo Son Min Chul Kim Jun Hyeob Ahn Kwang Jae Lee Min Jung Kwon Soon Hee Lee Jeong Hyun Park |
| author_sort | Jong Ho Kim |
| collection | DOAJ |
| description | Aim. The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus. Methods. This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) and estimated GFR (eGFR, <60 mL/min/1.73 m2 versus ≥60 mL/min/1.73 m2). Results. A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r=0.297, P<0.001) and eGFR (r=−0.220, P<0.001). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r=0.150, P<0.001). Also, baPWV was correlated positively with the ACR in patients with an eGFR ≥ 60 mL/min/1.73 m2 (r=0.146, P<0.001). However, baPWV was not correlated with eGFR after adjustment for significant clinical variables. Conclusions. The present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in GFR in patients with type 2 diabetes mellitus. |
| format | Article |
| id | doaj-art-f394e0655c824ada911076b66260aa09 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-f394e0655c824ada911076b66260aa092025-02-03T06:11:39ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/70479097047909Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND StudyJong Ho Kim0Sang Soo Kim1In Joo Kim2Bo Hyun Kim3Ja Young Park4Chang Won Lee5Ji Hye Suk6Sun Hae Shin7Sung Pyo Son8Min Chul Kim9Jun Hyeob Ahn10Kwang Jae Lee11Min Jung Kwon12Soon Hee Lee13Jeong Hyun Park14Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Pusan National University Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Pusan National University Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Pusan National University Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Busan St. Mary’s Medical Center, Busan, Republic of KoreaDepartment of Internal Medicine, Busan St. Mary’s Medical Center, Busan, Republic of KoreaDepartment of Internal Medicine, Woori Medical Clinic, Busan, Republic of KoreaDepartment of Internal Medicine, Bongseng Memorial Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Bongseng Memorial Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Ilsin Christian Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Good Moonhwa Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Daedong Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Pusan Paik Hospital, Inje University, Busan, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Pusan Paik Hospital, Inje University, Busan, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Pusan Paik Hospital, Inje University, Busan, Republic of KoreaAim. The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus. Methods. This multicenter cohort study analyzed 2613 patients with type 2 diabetes. Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) and estimated GFR (eGFR, <60 mL/min/1.73 m2 versus ≥60 mL/min/1.73 m2). Results. A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r=0.297, P<0.001) and eGFR (r=−0.220, P<0.001). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r=0.150, P<0.001). Also, baPWV was correlated positively with the ACR in patients with an eGFR ≥ 60 mL/min/1.73 m2 (r=0.146, P<0.001). However, baPWV was not correlated with eGFR after adjustment for significant clinical variables. Conclusions. The present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in GFR in patients with type 2 diabetes mellitus.http://dx.doi.org/10.1155/2017/7047909 |
| spellingShingle | Jong Ho Kim Sang Soo Kim In Joo Kim Bo Hyun Kim Ja Young Park Chang Won Lee Ji Hye Suk Sun Hae Shin Sung Pyo Son Min Chul Kim Jun Hyeob Ahn Kwang Jae Lee Min Jung Kwon Soon Hee Lee Jeong Hyun Park Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study Journal of Diabetes Research |
| title | Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study |
| title_full | Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study |
| title_fullStr | Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study |
| title_full_unstemmed | Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study |
| title_short | Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study |
| title_sort | arterial stiffness is more associated with albuminuria than decreased glomerular filtration rate in patients with type 2 diabetes mellitus the rebound study |
| url | http://dx.doi.org/10.1155/2017/7047909 |
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