The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics
Background. Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. Objectives. To analyze the association between FSTL1 and some parameters and inspect the rol...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/7918472 |
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| author | Yahui Liu Tian Liu Jinxiang Wu Tao Li Xingai Jiao Haiqing Zhang Jiping Zhao Junfei Wang Lin Liu Liuzhao Cao Shuo Li Jiawei Xu Jianfeng Xu Xiaohui Ma Lei Yang Liang Dong |
| author_facet | Yahui Liu Tian Liu Jinxiang Wu Tao Li Xingai Jiao Haiqing Zhang Jiping Zhao Junfei Wang Lin Liu Liuzhao Cao Shuo Li Jiawei Xu Jianfeng Xu Xiaohui Ma Lei Yang Liang Dong |
| author_sort | Yahui Liu |
| collection | DOAJ |
| description | Background. Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. Objectives. To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. Methods. We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed. Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy. Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters. Results. Plasma FSTL1 levels were higher in asthmatics (130.762 ± 46.029 ng/mL) than in controls (95.408 ± 33.938 ng/mL) (p=0.009). Plasma FSTL1 levels were associated with fibrosis levels around the airways (rs=0.529, p=0.043) and α-smooth muscle actin (α-SMA) (rs=0.554, p=0.032). FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (rs=0.536, p=0.040), α-SMA (rs=0.561, p=0.029), fibrosis levels (rs=0.779, p=0.001), and the thickness of the airway reticular basement membrane (RBM) (rs=0.660, p=0.007). Conclusions. FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM. FSTL1 may contribute to airway remodeling in asthmatics. |
| format | Article |
| id | doaj-art-f3894944da4b4ad0ab2aab41affdc561 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f3894944da4b4ad0ab2aab41affdc5612025-02-03T01:10:31ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/79184727918472The Correlation between FSTL1 Expression and Airway Remodeling in AsthmaticsYahui Liu0Tian Liu1Jinxiang Wu2Tao Li3Xingai Jiao4Haiqing Zhang5Jiping Zhao6Junfei Wang7Lin Liu8Liuzhao Cao9Shuo Li10Jiawei Xu11Jianfeng Xu12Xiaohui Ma13Lei Yang14Liang Dong15Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine-Bronchoscopy Room, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine-Bronchoscopy Room, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan 250012, ChinaBackground. Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. Objectives. To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma. Methods. We examined FSTL1 levels in 32 asthmatics and 25 controls. All subjects enrolled had routine blood tests, spirometry, and impulse oscillometry performed. Additionally, 15 of the 32 asthmatics underwent fibre optic bronchoscopy. Spearman rank analysis was performed to detect the correlation between FSTL1 and other parameters. Results. Plasma FSTL1 levels were higher in asthmatics (130.762 ± 46.029 ng/mL) than in controls (95.408 ± 33.938 ng/mL) (p=0.009). Plasma FSTL1 levels were associated with fibrosis levels around the airways (rs=0.529, p=0.043) and α-smooth muscle actin (α-SMA) (rs=0.554, p=0.032). FSTL1 levels in bronchoalveolar lavage fluid were associated with collagen I (rs=0.536, p=0.040), α-SMA (rs=0.561, p=0.029), fibrosis levels (rs=0.779, p=0.001), and the thickness of the airway reticular basement membrane (RBM) (rs=0.660, p=0.007). Conclusions. FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM. FSTL1 may contribute to airway remodeling in asthmatics.http://dx.doi.org/10.1155/2017/7918472 |
| spellingShingle | Yahui Liu Tian Liu Jinxiang Wu Tao Li Xingai Jiao Haiqing Zhang Jiping Zhao Junfei Wang Lin Liu Liuzhao Cao Shuo Li Jiawei Xu Jianfeng Xu Xiaohui Ma Lei Yang Liang Dong The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics Mediators of Inflammation |
| title | The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics |
| title_full | The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics |
| title_fullStr | The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics |
| title_full_unstemmed | The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics |
| title_short | The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics |
| title_sort | correlation between fstl1 expression and airway remodeling in asthmatics |
| url | http://dx.doi.org/10.1155/2017/7918472 |
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